Literature DB >> 19529986

Neurite outgrowth is dependent on the association of c-Src and lipid rafts.

Hui Zhao1, Xiaoding Cao, Gencheng Wu, Horace H Loh, Ping-Yee Law.   

Abstract

Regulation of neurite outgrowth is an important aspect not only for proper development of the nervous system but also for tissue regeneration after nerve injury and the treatment of neuropathological conditions. Here, we report that neurite outgrowth in cortical neuron and neuro 2A (N2A) cell was dependent on intact lipid rafts, as well as the enhanced localization of c-Src in the lipid rafts. Src inhibition or lipid rafts disruption could specifically block c-Src phosphorylation profile, pY416 Src increase and pY529 Src decrease, they also resulted in pY529 Src and c-terminal Src kinase (Csk) partition out of lipid rafts. Thus, we concluded that c-Src signal cascades within the lipid rafts is crucial for efficient neurite outgrowth.

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Year:  2009        PMID： 19529986     DOI： 10.1007/s11064-009-0016-7

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  40 in total

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