Pawel R Kiela1, Fayez K Ghishan. 1. Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Science Center, Tucson, AZ 85724, USA.
Abstract
PURPOSE OF REVIEW: In recent years, the field of intestinal physiology has witnessed significant progress in our understanding of the expression and function of ion transport proteins and their genes under physiological and pathophysiological conditions. This review will present some of these most recent advances in the small intestinal ion transport mechanisms. RECENT FINDINGS: One of the new and exciting aspects of this field has been the integration of function and structure of several intestinal transport processes. This is well exemplified by the discussed intricacies of intestinal bicarbonate secretion as well as the role of scaffolding PDZ proteins interacting with several transporters. We also discuss some of the most recent data pointing to the role of ion transporters in the pathogenesis of inflammation-associated diarrhea and their potential role in the maintenance of epithelial integrity. SUMMARY: Mouse models deficient in some of the key genes encoding ion transporters and their adapter proteins continue to provide important clues into intestinal transport processes. Several of the new in-vivo findings revise or complement past paradigms, many of which were derived from in-vitro approaches. New data on the interdependent functions of multiple transporters, as exemplified here by intestinal bicarbonate secretion, increase the complexity of the intestinal ion transport mechanisms and continue to contribute to a more integrated view of the transport phenomena in the gut. Data from patients and mouse models of intestinal inflammation also increase our understanding of the pathophysiology of inflammation-associated diarrhea.
PURPOSE OF REVIEW: In recent years, the field of intestinal physiology has witnessed significant progress in our understanding of the expression and function of ion transport proteins and their genes under physiological and pathophysiological conditions. This review will present some of these most recent advances in the small intestinal ion transport mechanisms. RECENT FINDINGS: One of the new and exciting aspects of this field has been the integration of function and structure of several intestinal transport processes. This is well exemplified by the discussed intricacies of intestinal bicarbonate secretion as well as the role of scaffolding PDZ proteins interacting with several transporters. We also discuss some of the most recent data pointing to the role of ion transporters in the pathogenesis of inflammation-associated diarrhea and their potential role in the maintenance of epithelial integrity. SUMMARY:Mouse models deficient in some of the key genes encoding ion transporters and their adapter proteins continue to provide important clues into intestinal transport processes. Several of the new in-vivo findings revise or complement past paradigms, many of which were derived from in-vitro approaches. New data on the interdependent functions of multiple transporters, as exemplified here by intestinal bicarbonate secretion, increase the complexity of the intestinal ion transport mechanisms and continue to contribute to a more integrated view of the transport phenomena in the gut. Data from patients and mouse models of intestinal inflammation also increase our understanding of the pathophysiology of inflammation-associated diarrhea.
Authors: P Jacob; S Christiani; H Rossmann; G Lamprecht; D Vieillard-Baron; R Müller; M Gregor; U Seidler Journal: Gastroenterology Date: 2000-08 Impact factor: 22.682
Authors: Janet E Simpson; Clifford W Schweinfest; Gary E Shull; Lara R Gawenis; Nancy M Walker; Kathryn T Boyle; Manoocher Soleimani; Lane L Clarke Journal: Am J Physiol Gastrointest Liver Physiol Date: 2006-12-14 Impact factor: 4.052
Authors: Jeffrey S Clark; David H Vandorpe; Marina N Chernova; John F Heneghan; Andrew K Stewart; Seth L Alper Journal: J Physiol Date: 2008-01-03 Impact factor: 5.182
Authors: Nellie Broere; Jutta Hillesheim; Biguang Tuo; Huub Jorna; Adriaan B Houtsmuller; Shirish Shenolikar; Edward J Weinman; Mark Donowitz; Ursula Seidler; Hugo R de Jonge; Boris M Hogema Journal: J Biol Chem Date: 2007-10-18 Impact factor: 5.157
Authors: Daniel Laubitz; Claire B Larmonier; Aiping Bai; Monica T Midura-Kiela; Maciej A Lipko; Robert D Thurston; Pawel R Kiela; Fayez K Ghishan Journal: Am J Physiol Gastrointest Liver Physiol Date: 2008-05-08 Impact factor: 4.052
Authors: Patrick R Cushing; Abigail Fellows; Daniel Villone; Prisca Boisguérin; Dean R Madden Journal: Biochemistry Date: 2008-08-29 Impact factor: 3.162
Authors: Svetlana M Nabokina; Veedamali S Subramanian; Hamid M Said Journal: Am J Physiol Gastrointest Liver Physiol Date: 2010-12-23 Impact factor: 4.052
Authors: L Laval; R Martin; J N Natividad; F Chain; S Miquel; C Desclée de Maredsous; S Capronnier; H Sokol; E F Verdu; J E T van Hylckama Vlieg; L G Bermúdez-Humarán; T Smokvina; P Langella Journal: Gut Microbes Date: 2015-01-14
Authors: Naren P Tallapragada; Hailey M Cambra; Tomas Wald; Samantha Keough Jalbert; Diana M Abraham; Ophir D Klein; Allon M Klein Journal: Cell Stem Cell Date: 2021-04-28 Impact factor: 25.269