OBJECTIVE: To examine occupational risk for Chronic Obstructive Pulmonary Disease (COPD). METHODS: We randomly recruited 233 subjects aged 55 to 75 reporting a physician's diagnosis of COPD, emphysema, or chronic bronchitis. Interviews assessed cigarette smoking and longest held job, identifying exposure to vapors, gas, dust, or fumes (VGDF). Lung function was assessed in n = 138. Comparison data were derived from a sample of referents without COPD. RESULTS: VGDF was reported in 123 (53%) of 233 cases versus 577 (34%) of 1709 referents. VGDF was associated with COPD (Odds Ratio [OR] 2.5; 95% CI = 1.9 to 3.4); the population attributable fraction was 32%. In the lung function subset, the FEV1/FVC was <70% in 79 (57%); 35 (44%) reported VGDF associated with an OR = 1.6 (95% CI = 0.99 to 2.6) and population attributable fraction 17%. CONCLUSIONS: These data support an important role for occupational exposures in COPD.
OBJECTIVE: To examine occupational risk for Chronic Obstructive Pulmonary Disease (COPD). METHODS: We randomly recruited 233 subjects aged 55 to 75 reporting a physician's diagnosis of COPD, emphysema, or chronic bronchitis. Interviews assessed cigarette smoking and longest held job, identifying exposure to vapors, gas, dust, or fumes (VGDF). Lung function was assessed in n = 138. Comparison data were derived from a sample of referents without COPD. RESULTS: VGDF was reported in 123 (53%) of 233 cases versus 577 (34%) of 1709 referents. VGDF was associated with COPD (Odds Ratio [OR] 2.5; 95% CI = 1.9 to 3.4); the population attributable fraction was 32%. In the lung function subset, the FEV1/FVC was <70% in 79 (57%); 35 (44%) reported VGDF associated with an OR = 1.6 (95% CI = 0.99 to 2.6) and population attributable fraction 17%. CONCLUSIONS: These data support an important role for occupational exposures in COPD.
Authors: P J Quinlan; G Earnest; M D Eisner; E H Yelin; P P Katz; J R Balmes; P D Blanc Journal: Occup Environ Med Date: 2008-09-19 Impact factor: 4.402
Authors: P D Blanc; S Ellbjär; C Janson; D Norbäck; E Norrman; P Plaschke; K Torén Journal: Am J Respir Crit Care Med Date: 1999-12 Impact factor: 21.405
Authors: P D Blanc; A M B Menezes; E Plana; D M Mannino; P C Hallal; K Toren; M D Eisner; J-P Zock Journal: Eur Respir J Date: 2008-11-14 Impact factor: 16.671
Authors: Paul D Blanc; Mark D Eisner; Edward H Yelin; Gillian Earnest; John R Balmes; Steven E Gregorich; Patricia P Katz Journal: Int J Chron Obstruct Pulmon Dis Date: 2008
Authors: Brent Doney; Eva Hnizdo; Monica Graziani; Greg Kullman; Cecil Burchfiel; Sherry Baron; Kaori Fujishiro; Paul Enright; John L Hankinson; Karen Hinckley Stukovsky; Christopher J Martin; Kathleen M Donohue; R Graham Barr Journal: COPD Date: 2014-02-25 Impact factor: 2.409
Authors: Laura M Paulin; Gregory B Diette; Paul D Blanc; Nirupama Putcha; Mark D Eisner; Richard E Kanner; Andrew J Belli; Stephanie Christenson; Donald P Tashkin; MeiLan Han; R Graham Barr; Nadia N Hansel Journal: Am J Respir Crit Care Med Date: 2015-03-01 Impact factor: 21.405
Authors: Michael D Weiden; Sophia Kwon; Erin Caraher; Kenneth I Berger; Joan Reibman; William N Rom; David J Prezant; Anna Nolan Journal: Semin Respir Crit Care Med Date: 2015-05-29 Impact factor: 3.119