Literature DB >> 1952871

In vitro enzymatic synthesis of new penicillins containing keto acids as side chains.

M A Ferrero1, A Reglero, H Martínez-Blanco, M Fernández-Valverde, J M Luengo.   

Abstract

Seven different penicillins containing alpha-ketobutyric, beta-ketobutyric, gamma-ketovaleric, alpha-ketohexanoic, delta-ketohexanoic, epsilon-ketoheptanoic, and alpha-ketooctanoic acids as side chains have been synthesized in vitro by incubating the enzymes phenylacetyl coenzyme A (CoA) ligase from Pseudomonas putida and acyl-CoA:6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum with CoA, ATP, Mg(2+), dithiothreitol, 6-aminopenicillanic acid, and the corresponding side chain precursor.

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Year:  1991        PMID： 1952871      PMCID： PMC245297          DOI： 10.1128/AAC.35.9.1931

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Fluorometric determination of phenylacetyl-CoA ligase from Pseudomonas putida: a very sensitive assay for a newly described enzyme.

Authors:  L B Rodríguez-Aparicio; A Reglero; H Martínez-Blanco; J M Luengo
Journal:  Biochim Biophys Acta       Date:  1991-03-04

2.  IV. Acyl-CoA: 6-APA acyltransferase of Penicillium chrysogenum: studies on substrate specificity using phenylacetyl-CoA variants.

Authors:  J Martín-Villacorta; A Reglero; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1989-10       Impact factor: 2.649

3.  Aliphatic molecules (C-6 to C-8) containing double or triple bonds as potential penicillin side-chain precursors.

Authors:  J Martín-Villacorta; A Reglero; M A Ferrero; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1990-12       Impact factor: 2.649

4.  Design of an enzymatic hybrid system: a useful strategy for the biosynthesis of benzylpenicillin in vitro.

Authors:  H Martínez-Blanco; A Reglero; J Martín-Villacorta; J M Luengo
Journal:  FEMS Microbiol Lett       Date:  1990-10       Impact factor: 2.742

5.  Enzymatic synthesis of penicillins.

Authors:  M J Alonso; F Bermejo; A Reglero; J M Fernández-Cañón; G González de Buitrago; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1988-08       Impact factor: 2.649

6.  Direct enzymatic synthesis of natural penicillins using phenylacetyl-CoA: 6-APA phenylacetyl transferase of Penicillium chrysogenum: minimal and maximal side chain length requirements.

Authors:  J M Luengo; J L Iriso; M J López-Nieto
Journal:  J Antibiot (Tokyo)       Date:  1986-12       Impact factor: 2.649

7.  Carbon catabolite regulation of phenylacetyl-CoA ligase from Pseudomonas putida.

Authors:  H Martinez-Blanco; A Reglero; J M Luengo
Journal:  Biochem Biophys Res Commun       Date:  1990-03-30       Impact factor: 3.575

8.  Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid.

Authors:  H Martínez-Blanco; A Reglero; L B Rodriguez-Aparicio; J M Luengo
Journal:  J Biol Chem       Date:  1990-04-25       Impact factor: 5.157

9.  Enzymatic approach to syntheses of unnatural beta-lactams.

Authors:  S Wolfe; A L Demain; S E Jensen; D W Westlake
Journal:  Science       Date:  1984-12-21       Impact factor: 47.728
  9 in total
  2 in total

1.  Homology modeling of the structure of acyl coA:isopenicillin N-acyltransferase (IAT) from Penicillium chrysogenum. IAT interaction studies with isopenicillin-N, combining molecular dynamics simulations and docking.

Authors:  Liliana Moreno-Vargas; Jose Correa-Basurto; Rachid C Maroun; Francisco J Fernández
Journal:  J Mol Model       Date:  2011-06-22       Impact factor: 1.810

2.  Improvement of the catalytic properties of penicillin G acylase from Escherichia coli ATCC 11105 by selection of a new substrate specificity.

Authors:  H Niersbach; A Kühne; W Tischer; M Weber; F Wedekind; R Plapp
Journal:  Appl Microbiol Biotechnol       Date:  1995 Aug-Sep       Impact factor: 4.813
  2 in total

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