BACKGROUND: Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas. MATERIALS AND METHODS: Three hundred and few tissues from gastric cancer patients were analyzed by immunohistochemical techniques using an anti-ERas antibody. ERas mRNA expression in 77 gastric carcinomas was examined by reverse-transcription polymerase chain reaction. RESULTS: ERas expression was positive in 135 (44%) of 304 gastric carcinomas. ERas-positive expression had a significant relationship with invasion depth (p<0.01), histological type (p<0.01), clinical stage (p=0.013) and curability (p=0.001). Prognosis of ERas-negative patients was significantly (p=0.029) poorer than that of ERas-positive patients, while ERas was not an independent prognostic factor. Expression of ERas mRNA was found in 35 (45%) out of 77 gastric cancer tissues. CONCLUSION: ERas oncogene is associated with the tumorigenic process of human gastric carcinomas.
BACKGROUND: Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas. MATERIALS AND METHODS: Three hundred and few tissues from gastric cancerpatients were analyzed by immunohistochemical techniques using an anti-ERas antibody. ERas mRNA expression in 77 gastric carcinomas was examined by reverse-transcription polymerase chain reaction. RESULTS:ERas expression was positive in 135 (44%) of 304 gastric carcinomas. ERas-positive expression had a significant relationship with invasion depth (p<0.01), histological type (p<0.01), clinical stage (p=0.013) and curability (p=0.001). Prognosis of ERas-negative patients was significantly (p=0.029) poorer than that of ERas-positive patients, while ERas was not an independent prognostic factor. Expression of ERas mRNA was found in 35 (45%) out of 77 gastric cancer tissues. CONCLUSION:ERas oncogene is associated with the tumorigenic process of humangastric carcinomas.
Authors: Fan Zhang; Jian Min Tang; Li Wang; Jing Ying Shen; Lin Zheng; Ping Ping Wu; Mei Zhang; Zhao Wen Yan Journal: Int J Clin Exp Pathol Date: 2010-11-01
Authors: Saeideh Nakhaei-Rad; Hossein Nakhaeizadeh; Silke Götze; Claus Kordes; Iris Sawitza; Michèle J Hoffmann; Manuel Franke; Wolfgang A Schulz; Jürgen Scheller; Roland P Piekorz; Dieter Häussinger; Mohammad R Ahmadian Journal: J Biol Chem Date: 2016-02-16 Impact factor: 5.157
Authors: Gerjon J Ikink; Mandy Boer; Elvira R M Bakker; Annabel Vendel-Zwaagstra; Chris Klijn; Jelle Ten Hoeve; Jos Jonkers; Lodewyk F Wessels; John Hilkens Journal: Oncogene Date: 2018-01-12 Impact factor: 9.867