| Literature DB >> 19528469 |
Hiroo Konishi1, Shojiro Kikuchi, Toshiya Ochiai, Hisashi Ikoma, Takeshi Kubota, Daisuke Ichikawa, Hitoshi Fujiwara, Kazuma Okamoto, Chouhei Sakakura, Teruhisa Sonoyama, Yukihito Kokuba, Hiroyuki Sasaki, Takeshi Matsui, Eigo Otsuji.
Abstract
Peritoneal dissemination of gastric cancer is a refractory disease. This paper focuses on the efficacy of actin-binding marine macrolide latrunculin A, which quickly inhibits actin polymerization and disrupts the function of the actin cytoskeleton. The effects of latrunculin A on cell viability in vitro were evaluated by treatment of MKN45 or NUGC-4 cell cultures. An in vitro viability assay demonstrated an anticancer effect of latrunculin A in a dose-dependent manner. Latrunculin A induced acute cell injury and programmed cell death through activating the caspase-3/7 pathway. In vivo, MKN45 or NUGC-4 cells were intraperitoneally inoculated into nude mice, as a model of peritoneal dissemination. Intraperitoneal (i.p.) injection of latrunculin A significantly improved survival rate in mice without any major side-effects. Data indicated that latrunculin A has strong anticancer effects, and it may be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in humans.Entities:
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Year: 2009 PMID： 19528469
Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480