BACKGROUND: 5-Hydroxymethylfurfural (HMF) is produced in large quantities during the processing of food containing carbohydrates and can be metabolised to 5-sulfooxymethylfurfural (SMF), a reactive intermediate that can bind to DNA and cause mutagenic effects. MATERIALS AND METHODS: Three to six days after birth, multiple intestinal neoplasia (Min/+) mice were given a single subcutaneous injection of either 500 mg/kg body weight (bw) HMF, 25 mg/kg bw SMF or vehicle (0.9 % NaCl), and were euthanised at 12 weeks of age. The number and size of adenomas and flat aberrant crypt foci (ACF) were counted in the intestine. RESULTS: HMF increased the number of small intestinal adenomas (p=0.033), whereas SMF increased the flat ACF number in the large intestine (p=0.025). Treatment with HMF and SMF had no effect on the size of the adenomas. CONCLUSION: These results show that both HMF and SMF are weak intestinal carcinogens in Min/+ mice.
BACKGROUND:5-Hydroxymethylfurfural (HMF) is produced in large quantities during the processing of food containing carbohydrates and can be metabolised to 5-sulfooxymethylfurfural (SMF), a reactive intermediate that can bind to DNA and cause mutagenic effects. MATERIALS AND METHODS: Three to six days after birth, multiple intestinal neoplasia (Min/+) mice were given a single subcutaneous injection of either 500 mg/kg body weight (bw) HMF, 25 mg/kg bw SMF or vehicle (0.9 % NaCl), and were euthanised at 12 weeks of age. The number and size of adenomas and flat aberrant crypt foci (ACF) were counted in the intestine. RESULTS:HMF increased the number of small intestinal adenomas (p=0.033), whereas SMF increased the flat ACF number in the large intestine (p=0.025). Treatment with HMF and SMF had no effect on the size of the adenomas. CONCLUSION: These results show that both HMF and SMF are weak intestinal carcinogens in Min/+ mice.
Authors: Benjamin Sachse; Walter Meinl; Yasmin Sommer; Hansruedi Glatt; Albrecht Seidel; Bernhard H Monien Journal: Arch Toxicol Date: 2014-11-05 Impact factor: 5.153
Authors: Mayada R Farag; Mahmoud Alagawany; May Bin-Jumah; Sarah I Othman; Asmaa F Khafaga; Hazem M Shaheen; Dalia Samak; Abdelrazeq M Shehata; Ahmed A Allam; Mohamed E Abd El-Hack Journal: Molecules Date: 2020-04-22 Impact factor: 4.411