OBJECTIVE: To determine whether there has been a demonstrable increase in the prevalence of human papillomavirus (HPV)-infected palatine tonsils corresponding to the increase in incidence of HPV-positive oropharyngeal squamous cell carcinoma (SCC) over time. DESIGN: Review of archived, paraffin-embedded, noncancerous palatine tonsils. SETTING: A single institution in El Paso County, Colorado. PATIENTS: Age- and sex-matched patients 21 years and older from 2 different periods: January 1, 1979, to December 31, 1982, (group A) and January 1, 1997, to December 31, 2001 (group B). MAIN OUTCOME MEASURES: Prevalence of oncogenic HPV-16 and HPV-18 in noncancerous palatine tonsils in relation to the incidence of HPV-positive oropharyngeal SCC. RESULTS: All specimens in both groups were negative for HPV-16 and HPV-18. Thus, the prevalence of HPV infection in the palatine tonsils of the general adult population was zero in both group A and group B. CONCLUSIONS: This analysis shows a low prevalence of HPV infection in the palatine tonsils of the general adult population in a single county in Colorado known to have an increasing rate of HPV-positive oropharyngeal SCC. Analysis of oropharyngeal tissues from individuals at highest risk of developing HPV-positive oropharyngeal SCC (middle-aged men) is likely to provide a higher prevalence rate.
OBJECTIVE: To determine whether there has been a demonstrable increase in the prevalence of human papillomavirus (HPV)-infected palatine tonsils corresponding to the increase in incidence of HPV-positive oropharyngeal squamous cell carcinoma (SCC) over time. DESIGN: Review of archived, paraffin-embedded, noncancerous palatine tonsils. SETTING: A single institution in El Paso County, Colorado. PATIENTS: Age- and sex-matched patients 21 years and older from 2 different periods: January 1, 1979, to December 31, 1982, (group A) and January 1, 1997, to December 31, 2001 (group B). MAIN OUTCOME MEASURES: Prevalence of oncogenic HPV-16 and HPV-18 in noncancerous palatine tonsils in relation to the incidence of HPV-positive oropharyngeal SCC. RESULTS: All specimens in both groups were negative for HPV-16 and HPV-18. Thus, the prevalence of HPV infection in the palatine tonsils of the general adult population was zero in both group A and group B. CONCLUSIONS: This analysis shows a low prevalence of HPV infection in the palatine tonsils of the general adult population in a single county in Colorado known to have an increasing rate of HPV-positive oropharyngeal SCC. Analysis of oropharyngeal tissues from individuals at highest risk of developing HPV-positive oropharyngeal SCC (middle-aged men) is likely to provide a higher prevalence rate.
Authors: Anna Holm; Alexandra Schindele; Annika Allard; Irene Eriksson; Karl Sandström; Göran Laurell; Karin Nylander; Katarina Olofsson Journal: Laryngoscope Investig Otolaryngol Date: 2019-04-12
Authors: Ahmet Volkan Sünter; Bahtiyar Hamit; Özgür Yiğit; Ela Araz Server; Elif Ömeroğlu Kara; Aysel Karataş; Mert Ahmet Kuşkucu; Yağmur Eylül Doğantürk; Kenan Midilli Journal: Turk Arch Otorhinolaryngol Date: 2019-09-01
Authors: Joanna Katarzyna Strzelczyk; Krzysztof Biernacki; Jadwiga Gaździcka; Elżbieta Chełmecka; Katarzyna Miśkiewicz-Orczyk; Natalia Zięba; Janusz Strzelczyk; Maciej Misiołek Journal: Diagnostics (Basel) Date: 2021-11-24
Authors: Marise da Penha Costa Marques; Ivo Bussoloti Filho; Lia Mara Rossi; Maria Antonieta Andreoli; Natália Oliveira Cruz Journal: Braz J Otorhinolaryngol Date: 2015-09-08