OBJECTIVE: To review a tertiary care pediatric hospital's experience with choanal atresia and stenosis (CA/S) related to associated congenital anomalies (birth defects, including minor abnormalities) and genetic disorders. DESIGN: Retrospective case series. SETTING: Tertiary care pediatric hospital. PATIENTS: Individuals with CA/S. MAIN OUTCOME MEASURES: Identification of congenital anomalies, neurologic abnormalities, and developmental disabilities in individuals with CA/S. RESULTS: One hundred twenty-nine individuals with CA/S were evaluated between July 1, 1997, and July 1, 2007. Choanal atresia and stenosis was an isolated finding in 34 patients (26.4%) and was associated with other anomalies in 95 patients (73.6%). Specific conditions were diagnosed in 66 patients (51.2%); CHARGE (coloboma, heart defect, atresia choanae, retarded growth, genitourinary abnormalities, and ear anomalies) syndrome was the most common diagnosis (33 patients [25.6%]). Numerous conditions were seen, including chromosomal abnormalities, single-gene defects, deformations, and those caused by teratogens. Choanal atresia and stenosis was unilateral in 62 patients (48.1%) and was bilateral in 60 patients (46.5%). Unilateral cases were more likely to be isolated (30 patients [53.2%]). Bilateral cases were more likely to be associated with specific disorders or multiple congenital anomalies (60 patients [98.4%]). There was no difference in laterality among unilateral cases. CONCLUSIONS: Choanal atresia and stenosis is associated with a wide range of disorders. Congenital anomalies, neurologic abnormalities, and developmental disabilities are commonly identified in affected individuals. Bilateral CA/S is more commonly seen in patients in whom specific diagnoses or other congenital anomalies are identified. Unilateral CA/S occurs more frequently in isolated cases. A comprehensive evaluation is recommended in individuals with CA/S to evaluate for other congenital anomalies, neurologic abnormalities, developmental delays, and evidence of a specific underlying disorder.
OBJECTIVE: To review a tertiary care pediatric hospital's experience with choanal atresia and stenosis (CA/S) related to associated congenital anomalies (birth defects, including minor abnormalities) and genetic disorders. DESIGN: Retrospective case series. SETTING: Tertiary care pediatric hospital. PATIENTS: Individuals with CA/S. MAIN OUTCOME MEASURES: Identification of congenital anomalies, neurologic abnormalities, and developmental disabilities in individuals with CA/S. RESULTS: One hundred twenty-nine individuals with CA/S were evaluated between July 1, 1997, and July 1, 2007. Choanal atresia and stenosis was an isolated finding in 34 patients (26.4%) and was associated with other anomalies in 95 patients (73.6%). Specific conditions were diagnosed in 66 patients (51.2%); CHARGE (coloboma, heart defect, atresia choanae, retarded growth, genitourinary abnormalities, and ear anomalies) syndrome was the most common diagnosis (33 patients [25.6%]). Numerous conditions were seen, including chromosomal abnormalities, single-gene defects, deformations, and those caused by teratogens. Choanal atresia and stenosis was unilateral in 62 patients (48.1%) and was bilateral in 60 patients (46.5%). Unilateral cases were more likely to be isolated (30 patients [53.2%]). Bilateral cases were more likely to be associated with specific disorders or multiple congenital anomalies (60 patients [98.4%]). There was no difference in laterality among unilateral cases. CONCLUSIONS:Choanal atresia and stenosis is associated with a wide range of disorders. Congenital anomalies, neurologic abnormalities, and developmental disabilities are commonly identified in affected individuals. Bilateral CA/S is more commonly seen in patients in whom specific diagnoses or other congenital anomalies are identified. Unilateral CA/S occurs more frequently in isolated cases. A comprehensive evaluation is recommended in individuals with CA/S to evaluate for other congenital anomalies, neurologic abnormalities, developmental delays, and evidence of a specific underlying disorder.
Authors: Kate M Lesciotto; Yann Heuzé; Ethylin Wang Jabs; Joseph M Bernstein; Joan T Richtsmeier Journal: Plast Reconstr Surg Date: 2018-01 Impact factor: 4.730
Authors: Azhar A Sh Hassan; Zainab S Bumuzah; Sara A Alomar; Ghadir A Alwabari; Zahra A AlAli; Zahra Y Al Abbas; Wasan M Alharbi; Shouq A Alraddadi; Dinah A AlNoaimi; Alaa K Alshammari Journal: Cureus Date: 2020-11-11
Authors: Josee Paradis; Agnieszka Dzioba; Hamdy El-Hakim; Paul Hong; Frederick K Kozak; Lily H P Nguyen; Demitri Perera; Evan Jon Propst; Jennifer M Siu; Monika Wojtera; Murad Husein Journal: J Otolaryngol Head Neck Surg Date: 2021-07-12