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Literature DB >> 19528288

Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.

Kerstin A Wolff¹, Hoa T Nguyen, Richard H Cartabuke, Ajay Singh, Sam Ogwang, Liem Nguyen.

Abstract

Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.

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Year: 2009 PMID： 19528288 PMCID： PMC2715596 DOI： 10.1128/AAC.00012-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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