Literature DB >> 1952809

Family data determine all parameters in Mendelian incomplete penetrance models.

A S Whittemore1, J B Keller, M J Ward.   

Abstract

We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.

Mesh:

Year:  1991        PMID: 1952809     DOI: 10.1111/j.1469-1809.1991.tb00410.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN: 0003-4800            Impact factor:   1.670


  2 in total

1.  Reports of the death of the epistasis model are greatly exaggerated.

Authors:  Martin Farrall
Journal:  Am J Hum Genet       Date:  2003-12       Impact factor: 11.025

2.  LOD wars: the affected-sib-pair paradigm strikes back!

Authors:  M Farrall
Journal:  Am J Hum Genet       Date:  1997-03       Impact factor: 11.025

  2 in total

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