Literature DB >> 19526843

[Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons].

H A Savchenko, A A Vasylevs'kyĭ, K A Pluzhnykov, Iu V Korol'kova, M V Mamenko, T M Volkova, O P Maksymiuk, Ia A Boĭchuk, Ie V Hrishyn, O O Kryshtal'.   

Abstract

Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

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Year:  2009        PMID： 19526843

Source DB:  PubMed          Journal:  Fiziol Zh        ISSN： 2522-9028


  3 in total

Review 1.  From toxins targeting ligand gated ion channels to therapeutic molecules.

Authors:  Adak Nasiripourdori; Valérie Taly; Thomas Grutter; Antoine Taly
Journal:  Toxins (Basel)       Date:  2011-03-21       Impact factor: 4.546

2.  Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors.

Authors:  Rômulo José Soares-Bezerra; Andrea Surrage Calheiros; Natiele Carla da Silva Ferreira; Valber da Silva Frutuoso; Luiz Anastacio Alves
Journal:  Pharmaceuticals (Basel)       Date:  2013-04-29

Review 3.  Action of natural products on p2 receptors: a reinvented era for drug discovery.

Authors:  Robson Faria; Leonardo Ferreira; Rômulo Bezerra; Valber Frutuoso; Luiz Alves
Journal:  Molecules       Date:  2012-11-01       Impact factor: 4.411
  3 in total

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