INTRODUCTION: The aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery. MATERIAL: Retrospective cohort study. METHODS: Included in this analysis are 276 consecutive patients with UICC disease stages III and IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; stage IV: 83.7%). All patients received preoperative radiochemotherapy (50Gy, Mitomycin and 5-Fluorouracil) and radical locoregional resection. RESULTS: Median surveillance period was 101.4 months (24-202 months). 5-year overall survival probability was 53.9%. 5-year local control probability was 70.2%. CONCLUSION: These results underline the reliability of preoperative treatment of patients with oral and oropharyngeal cancer.
INTRODUCTION: The aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery. MATERIAL: Retrospective cohort study. METHODS: Included in this analysis are 276 consecutive patients with UICC disease stages III and IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; stage IV: 83.7%). All patients received preoperative radiochemotherapy (50Gy, Mitomycin and 5-Fluorouracil) and radical locoregional resection. RESULTS: Median surveillance period was 101.4 months (24-202 months). 5-year overall survival probability was 53.9%. 5-year local control probability was 70.2%. CONCLUSION: These results underline the reliability of preoperative treatment of patients with oral and oropharyngeal cancer.
Authors: Stefan Riml; Franz Böhler; Lorenz Larcher; Alexander de Vries; Wolfgang Elsässer; Peter Kompatscher Journal: Wien Klin Wochenschr Date: 2012-08-01 Impact factor: 1.704
Authors: Matthias Kreppel; Sarah Danscheid; Martin Scheer; Jan Christoffer Lüers; Hans Theodor Eich; Joachim E Zöller; Orlando Guntinas-Lichius; Dirk Beutner Journal: Chemother Res Pract Date: 2012-09-29
Authors: Jens von der Grün; Ria Winkelmann; Iris Burck; Daniel Martin; Franz Rödel; Peter Johannes Wild; Katrin Bankov; Andreas Weigert; Ivan-Maximiliano Kur; Christian Brandts; Natalie Filmann; Christian Issing; Philipp Thönissen; Anna Maria Tanneberger; Claus Rödel; Shahram Ghanaati; Panagiotis Balermpas Journal: Front Oncol Date: 2022-03-24 Impact factor: 6.244