Literature DB >> 19524503

Bridging physiology and pathology in AD.

Dohoon Kim1, Li-Huei Tsai.   

Abstract

The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Abeta42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.

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Year:  2009        PMID： 19524503     DOI： 10.1016/j.cell.2009.05.042

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  36 in total

Review 1.  Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.

Authors:  Donat Kögel; Thomas Deller; Christian Behl
Journal:  Exp Brain Res       Date:  2011-11-16       Impact factor: 1.972

Review 2.  Genetics of dementia.

Authors:  Henry L Paulson; Indu Igo
Journal:  Semin Neurol       Date:  2012-01-21       Impact factor: 3.420

3.  Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model.

Authors:  Alessio Crestini; Paola Piscopo; Mariavittoria Iazeolla; Diego Albani; Roberto Rivabene; Gianluigi Forloni; Annamaria Confaloni
Journal:  J Mol Neurosci       Date:  2010-10-28       Impact factor: 3.444

Review 4.  Alzheimer's disease amyloid beta-protein and synaptic function.

Authors:  Tomas Ondrejcak; Igor Klyubin; Neng-Wei Hu; Andrew E Barry; William K Cullen; Michael J Rowan
Journal:  Neuromolecular Med       Date:  2009-09-16       Impact factor: 3.843

Review 5.  Is, indeed, the prion protein a Harlequin servant of "many" masters?

Authors:  M Catia Sorgato; Caterina Peggion; Alessandro Bertoli
Journal:  Prion       Date:  2009-10-04       Impact factor: 3.931

Review 6.  A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment.

Authors:  Brati Das; Riqiang Yan
Journal:  CNS Drugs       Date:  2019-03       Impact factor: 5.749

7.  Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Authors:  Hermeto Gerber; Fang Wu; Mitko Dimitrov; Guillermo M Garcia Osuna; Patrick C Fraering
Journal:  J Biol Chem       Date:  2017-01-17       Impact factor: 5.157

Review 8.  Calcium signaling and amyloid toxicity in Alzheimer disease.

Authors:  Angelo Demuro; Ian Parker; Grace E Stutzmann
Journal:  J Biol Chem       Date:  2010-03-08       Impact factor: 5.157

9.  APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

Authors:  Katherine L Youmans; Leon M Tai; Evelyn Nwabuisi-Heath; Lisa Jungbauer; Takahisa Kanekiyo; Ming Gan; Jungsu Kim; William A Eimer; Steve Estus; G William Rebeck; Edwin J Weeber; Guojun Bu; Chunjiang Yu; Mary Jo Ladu
Journal:  J Biol Chem       Date:  2012-10-11       Impact factor: 5.157

10.  Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells.

Authors:  Yuyoung Joo; Sungji Ha; Bo-Hyun Hong; Jeong a Kim; Keun-A Chang; Hyunjeong Liew; Seonghan Kim; Woong Sun; Joung-Hun Kim; Young Hae Chong; Yoo-Hun Suh; Hye-Sun Kim
Journal:  PLoS One       Date:  2010-12-02       Impact factor: 3.240
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