| Literature DB >> 19524434 |
H Bauke Albada1, Christopher J Arnusch, Hilbert M Branderhorst, Anne-Marie Verel, Wouter T M Janssen, Eefjan Breukink, Ben de Kruijff, Roland J Pieters, Rob M J Liskamp.
Abstract
The antibiotic vancomycin-that binds lipid II in the bacterial cell membrane-was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.Entities:
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Year: 2009 PMID： 19524434 DOI： 10.1016/j.bmcl.2009.05.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823