| Literature DB >> 19524418 |
Gui-Sheng Li1, Wang-Lin Jiang, Jing-Wei Tian, Gui-Wu Qu, Hai-Bo Zhu, Feng-Hua Fu.
Abstract
This study was carried out to investigate whether rosmarinic acid (RA) has antifibrotic effect on experimental liver fibrosis in vitro and in vivo and its possible mechanism. Culture of hepatic stellate cells (HSCs) determine proliferation and expression of transforming growth factor-beta1 (TGF-beta1), connective transforming growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA). In carbon tetrachloride (CCL(4))-induced rat liver fibrosis model, determined biochemical indicator, liver fibrosis grade and histopathological changes, immunohistochemical detected liver TGF-beta1 and CTGF expression. The results indicated that RA could inhibit HSCs proliferation, inhibit TGF-beta1, CTGF and alpha-SMA expression in cultured HSCs. It has marked evident in reducing fibrosis grade, ameliorating biochemical indicator and histopathological morphology, reducing liver TGF-beta1 and CTGF expression in CCL(4)-induced liver fibrosis. These findings suggest that RA has potentially conferring antifibrogenic effects. Copyright 2009 Elsevier GmbH. All rights reserved.Entities:
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Year: 2009 PMID： 19524418 DOI： 10.1016/j.phymed.2009.05.002
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340