Literature DB >> 19523928

Nicotinic acetylcholine receptors and the ascending dopamine pathways.

Phil D Livingstone1, Susan Wonnacott.   

Abstract

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. Thus nAChRs can influence the functions of these three pathways, notably motor control, 'reward' and executive function, respectively. Diverse subtypes of nAChRs have been identified on dopamine cell bodies and terminals as well as on neighbouring afferents and interneurons. Here we review the molecular and cellular mechanisms through which nAChRs exert their influence on these pathways in rodents.

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Year:  2009        PMID： 19523928     DOI： 10.1016/j.bcp.2009.06.004

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  57 in total

Review 1.  α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.

Authors:  Maryka Quik; Susan Wonnacott
Journal:  Pharmacol Rev       Date:  2011-12       Impact factor: 25.468

2.  α6ß2* and α4ß2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease.

Authors:  Xiomara A Perez; Tanuja Bordia; J Michael McIntosh; Maryka Quik
Journal:  Mol Pharmacol       Date:  2010-08-23       Impact factor: 4.436

Review 3.  Targeting nicotinic receptors for Parkinson's disease therapy.

Authors:  Maryka Quik; Tanuja Bordia; Luping Huang; Xiomara Perez
Journal:  CNS Neurol Disord Drug Targets       Date:  2011-09-01       Impact factor: 4.388

4.  Stimulation of nicotine reward and central cholinergic activity in Sprague-Dawley rats exposed perinatally to a fat-rich diet.

Authors:  Irene Morganstern; Olga Lukatskaya; Sang-Ho Moon; Wei-Ran Guo; Jane Shaji; Olga Karatayev; Sarah F Leibowitz
Journal:  Psychopharmacology (Berl)       Date:  2013-07-09       Impact factor: 4.530

5.  Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning.

Authors:  Morgane Milienne-Petiot; Kerin K Higa; Andrea Grim; Debbie Deben; Lucianne Groenink; Elizabeth W Twamley; Mark A Geyer; Jared W Young
Journal:  Eur Neuropsychopharmacol       Date:  2018-09-11       Impact factor: 4.600

Review 6.  Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.

Authors:  Maryka Quik; Xiomara A Perez; Sharon R Grady
Journal:  Biochem Pharmacol       Date:  2011-06-13       Impact factor: 5.858

Review 7.  Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions.

Authors:  Kalynda K Gonzales; Yoland Smith
Journal:  Ann N Y Acad Sci       Date:  2015-04-15       Impact factor: 5.691

8.  Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment.

Authors:  Matthew Brensilver; Keith G Heinzerling; Aimee-Noelle Swanson; Donatello Telesca; Benjamin A Furst; Steven J Shoptaw
Journal:  Drug Alcohol Rev       Date:  2012-03-04

Review 9.  The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior.

Authors:  J M Gulley; J M Juraska
Journal:  Neuroscience       Date:  2013-05-24       Impact factor: 3.590

10.  Frequency-Dependent Modulation of Dopamine Release by Nicotine and Dopamine D1 Receptor Ligands: An In Vitro Fast Cyclic Voltammetry Study in Rat Striatum.

Authors:  W Goutier; J P Lowry; A C McCreary; J J O'Connor
Journal:  Neurochem Res       Date:  2016-03-15       Impact factor: 3.996
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