Literature DB >> 19523893

How to Grb2 a Gab.

Franziska U Wöhrle1, Roger J Daly, Tilman Brummer.   

Abstract

In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Gab2.

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Year:  2009        PMID: 19523893     DOI: 10.1016/j.str.2009.05.003

Source DB:  PubMed          Journal:  Structure        ISSN: 0969-2126            Impact factor:   5.006


  7 in total

1.  Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.

Authors:  Caleb B McDonald; Vikas Bhat; David C Mikles; Brian J Deegan; Kenneth L Seldeen; Amjad Farooq
Journal:  FEBS J       Date:  2012-05-09       Impact factor: 5.542

2.  Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.

Authors:  Xiaocui Zhang; Genevieve Lavoie; Loic Fort; Edward L Huttlin; Joseph Tcherkezian; Jacob A Galan; Haihua Gu; Steven P Gygi; Sebastien Carreno; Philippe P Roux
Journal:  Mol Cell Biol       Date:  2013-02-11       Impact factor: 4.272

3.  Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.

Authors:  Xiaocui Zhang; Geneviève Lavoie; Antoine Méant; Léo Aubert; Marie Cargnello; André Haman; Trang Hoang; Philippe P Roux
Journal:  Mol Cell Biol       Date:  2017-03-17       Impact factor: 4.272

4.  BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.

Authors:  Ricarda Herr; Sebastian Halbach; Miriam Heizmann; Hauke Busch; Melanie Boerries; Tilman Brummer
Journal:  Oncogene       Date:  2018-01-12       Impact factor: 9.867

Review 5.  Structure and function of Gab2 and its role in cancer (Review).

Authors:  Chen-Bo Ding; Wei-Na Yu; Ji-Hong Feng; Jun-Min Luo
Journal:  Mol Med Rep       Date:  2015-06-17       Impact factor: 2.952

Review 6.  Intrinsically disordered proteins play diverse roles in cell signaling.

Authors:  Sarah E Bondos; A Keith Dunker; Vladimir N Uversky
Journal:  Cell Commun Signal       Date:  2022-02-17       Impact factor: 5.712

7.  Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.

Authors:  Sebastian Halbach; Kristoffer Tg Rigbolt; Franziska U Wöhrle; Britta Diedrich; Christine Gretzmeier; Tilman Brummer; Jörn Dengjel
Journal:  Cell Commun Signal       Date:  2013-04-22       Impact factor: 5.712

  7 in total

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