Literature DB >> 19523449

Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells.

Kei Ohnuma1, Masahiko Uchiyama, Ryo Hatano, Wataru Takasawa, Yuko Endo, Nam H Dang, Chikao Morimoto.   

Abstract

CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19523449     DOI： 10.1016/j.bbrc.2009.06.027

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

Review 1.  Caveolin-1: a critical regulator of lung injury.

Authors:  Yang Jin; Seon-Jin Lee; Richard D Minshall; Augustine M K Choi
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-11-19       Impact factor: 5.464

Review 2.  Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system.

Authors:  C Klemann; L Wagner; M Stephan; S von Hörsten
Journal:  Clin Exp Immunol       Date:  2016-05-13       Impact factor: 4.330

3.  Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes.

Authors:  Kei Ohnuma; Ryo Hatano; Thomas M Aune; Haruna Otsuka; Satoshi Iwata; Nam H Dang; Taketo Yamada; Chikao Morimoto
Journal:  J Immunol       Date:  2015-03-18       Impact factor: 5.422

4.  Serum levels of soluble CD26 and CD30 and their clinical significance in patients with rheumatoid arthritis.

Authors:  Hasan Ulusoy; Ayhan Kamanli; Necip Ilhan; Omer Kuru; Sule Arslan; Gokhan Alkan; Salih Ozgocmen
Journal:  Rheumatol Int       Date:  2011-12-23       Impact factor: 2.631

5.  Degranulation of human cytotoxic lymphocytes is a major source of proteolytically active soluble CD26/DPP4.

Authors:  Marcus Lettau; Michelle Dietz; Sarah Vollmers; Fred Armbrust; Christian Peters; Thi Mai Dang; Guranda Chitadze; Dieter Kabelitz; Ottmar Janssen
Journal:  Cell Mol Life Sci       Date:  2019-07-12       Impact factor: 9.261

6.  Role of caveolin-3 in lymphocyte activation.

Authors:  Chinh Tran; Creed M Stary; Jan M Schilling; Brandon Bentley; Hemal H Patel; David M Roth
Journal:  Life Sci       Date:  2014-12-02       Impact factor: 5.037

Review 7.  Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.

Authors:  Brian P Head; Hemal H Patel; Paul A Insel
Journal:  Biochim Biophys Acta       Date:  2013-07-27

8.  Delayed allogeneic skin graft rejection in CD26-deficient mice.

Authors:  Xiangli Zhao; Kai Zhang; Peter Daniel; Natali Wisbrun; Hendrik Fuchs; Hua Fan
Journal:  Cell Mol Immunol       Date:  2018-03-23       Impact factor: 11.530

9.  A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice.

Authors:  Hiroyuki Hirakawa; Hirofumi Zempo; Masahito Ogawa; Ryo Watanabe; Jun-Ichi Suzuki; Hiroshi Akazawa; Issei Komuro; Mitsuaki Isobe
Journal:  PLoS One       Date:  2015-03-13       Impact factor: 3.240

10.  Dipeptidyl peptidase-4 inhibitors have adverse effects for the proliferation of human T cells.

Authors:  Noriyuki Kitagawa; Masahide Hamaguchi; Saori Majima; Takuya Fukuda; Toshihiro Kimura; Yoshitaka Hashimoto; Muhei Tanaka; Masahiro Yamazaki; Naoto Nakamura; Michiaki Fukui
Journal:  J Clin Biochem Nutr       Date:  2018-04-03       Impact factor: 3.114
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.