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Literature DB >> 195228

Acetylcholine and cAMP in adrenal medulla:indirect effect.

Abstract

Catecholamine release and cAMP accumulation were studied in bovine adrenal medulla slices in vitro. Acetylcholine (10(-4) M) and salbutamol (10(-6) M) caused increased release of catecholamines and accumulation of cAMP. Incubation in Ca2+ -free medium abolished the release of catecholamines and the increase of cAMP caused by acetylcholine but not that caused by salbutamol. In a membrane fraction of adrenal medulla acetylcholine (10(-4) M) had no effect on adenylate cyclase activity but salbutamol (10(-6) M) caused substantial activation of adenylate cyclase. It is suggested that acetylcholine has no direct effect on adenylate cyclase or cAMP in adrenal medulla and the accumulation of cAMP observed in slices incubated with acetylcholine is due to the effect of catecholamines, released by acetylcholine, on the medullary cells.

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Year: 1977 PMID： 195228 DOI： 10.1007/bf00509267

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

8 in total

1. Effect of hypophysectomy on cAMP changes in rat adrenal medulla evoked by catecholamines and carbamylcholine.

Authors: U Otten; R A Mueller; H Thoenen
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

2. Adenyl cyclase activity in bovine adrenal medulla.

Authors: G Serck-Hanssen; T Christoffersen; J Morland; J B Osnes
Journal: Eur J Pharmacol Date: 1972-08 Impact factor: 4.432

3. Involvement of adenosine 3',5'-monophosphate in the activation of tyrosine hydroxylase elicited by drugs.

Authors: A Guidotti; E Costa
Journal: Science Date: 1973-03-02 Impact factor: 47.728

4. Involvement of 3',5'-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure.

Authors: A Guidotti; B Zivkovic; R Pfeiffer; E Costa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

5. A role for nicotinic receptors in the regulation of the adenylate cyclase of adrenal medulla.

Authors: A Guidotti; E Costa
Journal: J Pharmacol Exp Ther Date: 1974-06 Impact factor: 4.030

6. Further evidence for nicotinic and muscarinic receptors and their interaction in dog adrenal medulla.

Authors: A Tsujimoto; T Nishikawa
Journal: Eur J Pharmacol Date: 1975-12 Impact factor: 4.432

7. Induction of tyrosine hydroxylase elicited by beta adrenergic receptor agonists in normal and decentralized sympathetic ganglia: role of cyclic 3',5' - adenosine monophosphate.

Authors: I Hanbauer; I J Kopin; A Guidotti; E Costa
Journal: J Pharmacol Exp Ther Date: 1975-04 Impact factor: 4.030

8. Alpha-adrenergic stimulants, prostaglandins and catecholamine release from the adrenal gland in vitro.

Authors: P Boonyaviroj; Y Gutman
Journal: Prostaglandins Date: 1975-07

8 in total

6 in total

4. Differential effects of D600, nifedipine and dantrolene sodium on excitation-secretion coupling and presynaptic beta-adrenoceptor responses in rat atria.

Authors: K M Callanan; A K Keenan
Journal: Br J Pharmacol Date: 1984-11 Impact factor: 8.739

5. Effects of verapamil, dantrolene and lanthanum on catecholamine release from rat adrenal medulla.

Authors: J Cohen; Y Gutman
Journal: Br J Pharmacol Date: 1979-04 Impact factor: 8.739

6. Local modulation of adrenal catecholamines release by beta-2 adrenoceptors in the anaesthetized dog.

Authors: S Foucart; R Nadeau; J de Champlain
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-01 Impact factor: 3.000