BACKGROUND AND PURPOSE: Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity. CONCLUSIONS: These anecdotal electrocorticographic findings suggest that ketamine has an inhibitory effect on spreading depolarizations in humans. This is of potential interest for future neuroprotective trials.
BACKGROUND AND PURPOSE: Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity. CONCLUSIONS: These anecdotal electrocorticographic findings suggest that ketamine has an inhibitory effect on spreading depolarizations in humans. This is of potential interest for future neuroprotective trials.
Authors: Ana I Oliveira-Ferreira; Denny Milakara; Mesbah Alam; Devi Jorks; Sebastian Major; Jed A Hartings; Janos Lückl; Peter Martus; Rudolf Graf; Christian Dohmen; Georg Bohner; Johannes Woitzik; Jens P Dreier Journal: J Cereb Blood Flow Metab Date: 2010-03-24 Impact factor: 6.200
Authors: Martin Lauritzen; Jens Peter Dreier; Martin Fabricius; Jed A Hartings; Rudolf Graf; Anthony John Strong Journal: J Cereb Blood Flow Metab Date: 2010-11-03 Impact factor: 6.200
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Authors: Guenther Herzer; Claudia Mirth; Udo M Illievich; Wolfgang G Voelckel; Helmut Trimmel Journal: Wien Klin Wochenschr Date: 2017-07-21 Impact factor: 1.704
Authors: Hajime Nakamura; Anthony J Strong; Christian Dohmen; Oliver W Sakowitz; Stefan Vollmar; Michael Sué; Lutz Kracht; Parastoo Hashemi; Robin Bhatia; Toshiki Yoshimine; Jens P Dreier; Andrew K Dunn; Rudolf Graf Journal: Brain Date: 2010-05-26 Impact factor: 13.501