Literature DB >> 19520551

In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii.

Rossana de Aguiar Cordeiro1, Raimunda Sâmia Nogueira Brilhante, Marcos Fábio Gadelha Rocha, Delia Jessica Astete Medrano, André Jalles Monteiro, Juliane Lira Tavares, Rita Amanda Chaves de Lima, Zoilo Pires de Camargo, José Júlio Costa Sidrim.   

Abstract

The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) with antifungals against Coccidioides posadasii. Eighteen drug combinations, formed by an ATD (isoniazid, pyrazinamide or ethambutol) plus an antifungal (amphotericin B, ketoconazole, itraconazole, fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combinations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in the combinations formed by triazoles plus ethambutol as well as itraconazole plus pyrazinamide. Further studies in animal models are needed to confirm the usefulness of these combinations.

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Year:  2009        PMID： 19520551     DOI： 10.1016/j.ijantimicag.2009.04.009

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  3 in total

1.  Synergistic effect of antituberculosis drugs and azoles in vitro against Histoplasma capsulatum var. capsulatum.

Authors:  Rossana de Aguiar Cordeiro; Francisca Jakelyne de Farias Marques; Raimunda Sâmia Nogueira Brilhante; Kylvia Rocha de Castro E Silva; Charles Ielpo Mourão; Erica Pacheco Caetano; Maria Auxiliadora Bezerra Fechine; Joyce Fonteles Ribeiro; Débora de Souza Collares Maia Castelo-Branco; Rita Amanda Chaves de Lima; Jacó Ricarte Lima Mesquita; Andre Jalles Monteiro; Francisco Airton Castro Rocha; Marcos Fábio Gadelha Rocha; José Júlio Costa Sidrim
Journal:  Antimicrob Agents Chemother       Date:  2011-06-20       Impact factor: 5.191

2.  Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii.

Authors:  Raimunda Sâmia Nogueira Brilhante; Rita Amanda Chaves de Lima; Erica Pacheco Caetano; João Jaime Giffoni Leite; Débora de Souza Collares Maia Castelo-Branco; Joyce Fonteles Ribeiro; Tereza de Jesus Pinheiro Gomes Bandeira; Rossana de Aguiar Cordeiro; André Jalles Monteiro; José Júlio Costa Sidrim; Marcos Fábio Gadelha Rocha
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

3.  Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi.

Authors:  Raimunda Sâmia Nogueira Brilhante; Érica Pacheco Caetano; Rita Amanda Chaves de Lima; Francisca Jakelyne de Farias Marques; Débora de Souza Collares Maia Castelo-Branco; Charlline Vládia Silva de Melo; Glaucia Morgana de Melo Guedes; Jonathas Sales de Oliveira; Zoilo Pires de Camargo; José Luciano Bezerra Moreira; André Jalles Monteiro; Tereza de Jesus Pinheiro Gomes Bandeira; Rossana de Aguiar Cordeiro; Marcos Fábio Gadelha Rocha; José Júlio Costa Sidrim
Journal:  Braz J Microbiol       Date:  2016-07-26       Impact factor: 2.214
  3 in total

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