PURPOSE: To analyze the topography of the epileptogenic zone (EZ) and the etiologic substrate as risk factors for sleep-related focal epilepsy. METHODS: Three hundred three patients (172 males and 131 females, mean age at surgery 25.6 +/- 13.1 years), who were seizure-free after resective surgery for drug-resistant focal epilepsy, were retrospectively reviewed. Statistical analysis was conducted to evaluate the risk of presenting sleep-related epilepsy (SRE) against topography of resection (assumed to correspond or to include the EZ) and results of histology. RESULTS: Thirty-nine patients (12.8%) presented with an SRE. At bivariate analysis, a higher frequency of SRE was associated with a frontal lobe EZ (p = 1.94 x 10(-9)) and Taylor's FCD (TFCD, p = 2.20 x 10(-16)), whereas architectural FCD (p = 0.00977), ganglioglioma (p = 0.02508), and mesial temporal sclerosis (p = 2.47 x 10(-5)) were correlated with a reduced frequency of SRE. Multivariate analysis demonstrated that the only variable significantly associated with SRE was the presence of a TFCD, which increased 14-fold the risk of SRE [p = 1.66 x 10(-10); risk ratio (RR) = 14.44]. DISCUSSION: In this study, we have demonstrated a significant and strong association between SRE and TFCD in a select population of patients with drug-resistant focal epilepsy submitted to surgical resection of the EZ. Although our results cannot be applied to the entire spectrum of SRE, the presence of TFCD as the underlying etiology should be considered when evaluating patients with SRE, because surgery can provide excellent results on seizures in these cases.
PURPOSE: To analyze the topography of the epileptogenic zone (EZ) and the etiologic substrate as risk factors for sleep-related focal epilepsy. METHODS: Three hundred three patients (172 males and 131 females, mean age at surgery 25.6 +/- 13.1 years), who were seizure-free after resective surgery for drug-resistant focal epilepsy, were retrospectively reviewed. Statistical analysis was conducted to evaluate the risk of presenting sleep-related epilepsy (SRE) against topography of resection (assumed to correspond or to include the EZ) and results of histology. RESULTS: Thirty-nine patients (12.8%) presented with an SRE. At bivariate analysis, a higher frequency of SRE was associated with a frontal lobe EZ (p = 1.94 x 10(-9)) and Taylor's FCD (TFCD, p = 2.20 x 10(-16)), whereas architectural FCD (p = 0.00977), ganglioglioma (p = 0.02508), and mesial temporal sclerosis (p = 2.47 x 10(-5)) were correlated with a reduced frequency of SRE. Multivariate analysis demonstrated that the only variable significantly associated with SRE was the presence of a TFCD, which increased 14-fold the risk of SRE [p = 1.66 x 10(-10); risk ratio (RR) = 14.44]. DISCUSSION: In this study, we have demonstrated a significant and strong association between SRE and TFCD in a select population of patients with drug-resistant focal epilepsy submitted to surgical resection of the EZ. Although our results cannot be applied to the entire spectrum of SRE, the presence of TFCD as the underlying etiology should be considered when evaluating patients with SRE, because surgery can provide excellent results on seizures in these cases.
Authors: Daniel Noli; Marcelo Bartuluchi; Federico Sanchez González; María Carolina Kaltenmeier; Ricardo Cersosimo; Carlos Rugilo; Juan P Princich; Fabiana Lubieniecki; Hugo Pomata; Roberto Caraballo Journal: Childs Nerv Syst Date: 2013-07-07 Impact factor: 1.475
Authors: Ingmar Blümcke; Maria Thom; Eleonora Aronica; Dawna D Armstrong; Harry V Vinters; Andre Palmini; Thomas S Jacques; Giuliano Avanzini; A James Barkovich; Giorgio Battaglia; Albert Becker; Carlos Cepeda; Fernando Cendes; Nadia Colombo; Peter Crino; J Helen Cross; Olivier Delalande; François Dubeau; John Duncan; Renzo Guerrini; Philippe Kahane; Gary Mathern; Imad Najm; Ciğdem Ozkara; Charles Raybaud; Alfonso Represa; Steven N Roper; Noriko Salamon; Andreas Schulze-Bonhage; Laura Tassi; Annamaria Vezzani; Roberto Spreafico Journal: Epilepsia Date: 2010-11-10 Impact factor: 5.864
Authors: Inês Menezes Cordeiro; Nicolas von Ellenrieder; Natalja Zazubovits; François Dubeau; Jean Gotman; Birgit Frauscher Journal: Epilepsy Res Date: 2015-04-08 Impact factor: 3.045
Authors: Paolo Tinuper; Francesca Bisulli; J H Cross; Dale Hesdorffer; Philippe Kahane; Lino Nobili; Federica Provini; Ingrid E Scheffer; Laura Tassi; Luca Vignatelli; Claudio Bassetti; Fabio Cirignotta; Christopher Derry; Antonio Gambardella; Renzo Guerrini; Peter Halasz; Laura Licchetta; Mark Mahowald; Raffaele Manni; Carla Marini; Barbara Mostacci; Ilaria Naldi; Liborio Parrino; Fabienne Picard; Maura Pugliatti; Philippe Ryvlin; Federico Vigevano; Marco Zucconi; Samuel Berkovic; Ruth Ottman Journal: Neurology Date: 2016-04-15 Impact factor: 9.910
Authors: Lorenzo Ferri; Francesca Bisulli; Lino Nobili; Laura Tassi; Laura Licchetta; Barbara Mostacci; Carlotta Stipa; Greta Mainieri; Giorgia Bernabè; Federica Provini; Paolo Tinuper Journal: Sleep Med Date: 2014-08-15 Impact factor: 3.492