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Literature DB >> 19519499

RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery.

Abstract

The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.

Entities: Disease Gene

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Year: 2009 PMID： 19519499 DOI： 10.2174/138955709788452748

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

9 in total

1. Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions.

Authors: Yadira Palacios-Rodríguez; Guillermo García-Laínez; Mónica Sancho; Anna Gortat; Mar Orzáez; Enrique Pérez-Payá
Journal: J Biol Chem Date: 2011-11-07 Impact factor: 5.157

2. 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.

Authors: Khadijeh Bijangi-Vishehsaraei; Mohammad Reza Saadatzadeh; Su Huang; Ahmad R Safa; Michael P Murphy
Journal: Mol Cell Biochem Date: 2010-05-06 Impact factor: 3.396

RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery.

1. Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions.

2. 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.

Review 3. Apoptotic cell signaling in cancer progression and therapy.

4. A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma.

Review 5. Autophagy genes as tumor suppressors.

6. Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.

Review 7. Apoptosis regulation in adrenocortical carcinoma.

Review 8. Cyclodextrins in non-viral gene delivery.

Review 9. Apoptosis and molecular targeting therapy in cancer.