Literature DB >> 19519495

3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds.

P Hradil1, J Hlavác, M Soural, M Hajdúch, M Kolár, R Vecerová.   

Abstract

2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.

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Year:  2009        PMID： 19519495     DOI： 10.2174/138955709788452720

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  8 in total

1.  Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors.

Authors:  Sivaprasad Kasturi; Sujatha Surarapu; Chandra Chary Bathoju; Srinivas Uppalanchi; Shubham Dwivedi; Yogeeswari Perumal; Dilep Kumar Sigalapalli; Bathini Nagendra Babu; Krishna S Ethiraj; Jaya Shree Anireddy
Journal:  Medchemcomm       Date:  2017-06-14       Impact factor: 3.597

2.  A novel microwave synthesis of quinoline-3-carboxylic acid derivatives for treatment against human African trypanosomiasis.

Authors:  Bhupesh S Samant; Nyaradzai Nyangari
Journal:  Mol Divers       Date:  2012-10-10       Impact factor: 2.943

3.  Unusual Friedlander reactions: a route to novel quinoxaline-based heterocycles.

Authors:  Tharallah A Shoker; Khaled I Ghattass; James C Fettinger; Mark J Kurth; Makhluf J Haddadin
Journal:  Org Lett       Date:  2012-07-11       Impact factor: 6.005

4.  Oxidative formation of bis-N-methylquinolinone from anti-head-to-head N-methylquinolinone cyclodimer.

Authors:  Nikolai Bieniek; Christian P Haas; Ulrich Tallarek; Norbert Hampp
Journal:  Photochem Photobiol Sci       Date:  2021-06-12       Impact factor: 3.982

5.  Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones.

Authors:  Soňa Krajčovičová; Jan Hlaváč; Kristýna Vychodilová
Journal:  RSC Adv       Date:  2021-03-02       Impact factor: 3.361

6.  Cytotoxicity of Amino-BODIPY Modulated via Conjugation with 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones.

Authors:  Martin Porubský; Kristýna Vychodilová; David Milićević; Miloš Buděšinský; Jarmila Stanková; Petr Džubák; Marián Hajdúch; Jan Hlaváč
Journal:  ChemistryOpen       Date:  2021-08-23       Impact factor: 2.630

7.  Identification of components in Kazakhstan honeys that correlate with antimicrobial activity against wound and skin infecting microorganisms.

Authors:  Pauline McLoone; Aizhan Zhumbayeva; Sofiya Yunussova; Yerkhat Kaliyev; Ludmila Yevstafeva; Susan Verrall; Julie Sungurtas; Ceri Austin; J Will Allwood; Gordon J McDougall
Journal:  BMC Complement Med Ther       Date:  2021-12-20

Review 8.  Recent syntheses of 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1H)-quinolinones and 4(1H)-quinolinones using domino reactions.

Authors:  Baskar Nammalwar; Richard A Bunce
Journal:  Molecules       Date:  2013-12-24       Impact factor: 4.411
  8 in total

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