Literature DB >> 19519349

Structure, expression, and regulation of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase (DPAGT1).

Roger K Bretthauer1.   

Abstract

Glycosylation of proteins on asparagine amino acids (N-linked) in proteins of eukaryotic cells is initiated by the biosynthesis of dolichol-pyrophosphate-N-acetylglucosamine from dolichol-phosphate and UDP-N-acetylglucosamine. The enzyme catalyzing this reaction, UDP-GlcNAc:Dolichol Phosphate GlcNAc-1-Phosphate Transferase (DPAGT1), has been further characterized in several cell types with respect to its gene, gene products, membrane topology, functional sites, lipid dependence, and metabolic regulation. This review summarizes these properties as an update from an earlier detailed and critical review by Lehrman (Lehrman, M. A. (1991) Glycobiology, 1, 553-562).

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Year:  2009        PMID： 19519349     DOI： 10.2174/138945009788488369

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  15 in total

1.  A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.

Authors:  Jan H Reiling; Clary B Clish; Jan E Carette; Malini Varadarajan; Thijn R Brummelkamp; David M Sabatini
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-15       Impact factor: 11.205

2.  Identification of DPAGT1 as a new gene in which mutations cause a congenital myasthenic syndrome.

Authors:  Katsiaryna Belaya; Sarah Finlayson; Judith Cossins; Wei Wei Liu; Susan Maxwell; Jacqueline Palace; David Beeson
Journal:  Ann N Y Acad Sci       Date:  2012-12       Impact factor: 5.691

Review 3.  N-glycans in cell survival and death: cross-talk between glycosyltransferases.

Authors:  Dipak K Banerjee
Journal:  Biochim Biophys Acta       Date:  2012-02-03

4.  Clinical features of congenital myasthenic syndrome due to mutations in DPAGT1.

Authors:  Sarah Finlayson; Jacqueline Palace; Katsiaryna Belaya; Timothy J Walls; Fiona Norwood; Georgina Burke; Janice L Holton; Samuel I Pascual-Pascual; Judith Cossins; David Beeson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2013-02-27       Impact factor: 10.154

5.  Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

Authors:  Katsiaryna Belaya; Sarah Finlayson; Clarke R Slater; Judith Cossins; Wei Wei Liu; Susan Maxwell; Simon J McGowan; Siarhei Maslau; Stephen R F Twigg; Timothy J Walls; Samuel I Pascual Pascual; Jacqueline Palace; David Beeson
Journal:  Am J Hum Genet       Date:  2012-06-27       Impact factor: 11.025

6.  Tunicamycin depresses P-glycoprotein glycosylation without an effect on its membrane localization and drug efflux activity in L1210 cells.

Authors:  Mário Sereš; Dana Cholujová; Tatiana Bubenčíkova; Albert Breier; Zdenka Sulová
Journal:  Int J Mol Sci       Date:  2011-11-10       Impact factor: 5.923

Review 7.  (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy.

Authors:  Carine Beaupere; Vyacheslav M Labunskyy
Journal:  Curr Genet       Date:  2018-12-03       Impact factor: 2.695

8.  Congenital myasthenic syndromes due to mutations in ALG2 and ALG14.

Authors:  Judith Cossins; Katsiaryna Belaya; Debbie Hicks; Mustafa A Salih; Sarah Finlayson; Nicola Carboni; Wei Wei Liu; Susan Maxwell; Katarzyna Zoltowska; Golara Torabi Farsani; Steven Laval; Mohammed Zain Seidhamed; Peter Donnelly; David Bentley; Simon J McGowan; Juliane Müller; Jacqueline Palace; Hanns Lochmüller; David Beeson
Journal:  Brain       Date:  2013-02-11       Impact factor: 13.501

9.  Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Authors:  Carine Beaupere; Leticia Dinatto; Brian M Wasko; Rosalyn B Chen; Lauren VanValkenburg; Michael G Kiflezghi; Mitchell B Lee; Daniel E L Promislow; Weiwei Dang; Matt Kaeberlein; Vyacheslav M Labunskyy
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-05       Impact factor: 12.779

Review 10.  Inherited disorders of the neuromuscular junction: an update.

Authors:  Pedro M Rodríguez Cruz; Jacqueline Palace; David Beeson
Journal:  J Neurol       Date:  2014-10-11       Impact factor: 4.849
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