| Literature DB >> 19515564 |
Antony N Shaw1, Rosanna Tedesco, Ramesh Bambal, Deping Chai, Nestor O Concha, Michael G Darcy, Dashyant Dhanak, Kevin J Duffy, Duke M Fitch, Adam Gates, Victor K Johnston, Richard M Keenan, Juili Lin-Goerke, Nannan Liu, Robert T Sarisky, Kenneth J Wiggall, Michael N Zimmerman.
Abstract
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative.Entities:
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Year: 2009 PMID： 19515564 DOI： 10.1016/j.bmcl.2009.05.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823