| Literature DB >> 19515562 |
Guang-Xiang Zhong1, Lu-Lu Chen, Hai-Bo Li, Fu-Jin Liu, Jin-Qing Hu, Wei-Xiao Hu.
Abstract
To discover the new medicinal activity, the structure of diflunisal has been modified. Forty amide derivatives of diflunisal were synthesized starting from diflunisal in three steps. Their inhibition growth rate of human lung cancer cell (A549) and human endometrial adenocarcinoma cell (Ishikawa) in vitro was evaluated. The preliminary assay results showed that compounds 6j, 7o and 8c exhibited good anti-tumor activities and excellent selectivity for the Ishikawa cell, may be potential anti-tumor agents.Entities:
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Year: 2009 PMID： 19515562 DOI： 10.1016/j.bmcl.2009.05.082
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823