OBJECTIVES: To test the hypothesis that low circulating brain-derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all-cause mortality in 85-year-old men and women. DESIGN: Longitudinal study with 50- to 58-month follow-up. SETTING: The 1914 cohort, a population-based cohort established in 1964 by the Research Center for Prevention and Health at Glostrup Hospital. PARTICIPANTS: One hundred eighty-eight unselected 85-year-old Danes. MEASUREMENTS: BDNF was measured in plasma and serum. The Danish National Register of Patients was used to collect data on morbidity. The primary outcome in Cox regression analyses was all-cause mortality. RESULTS: Women with low plasma BDNF (lowest tertile) had greater all-cause mortality risk than women with high plasma BDNF (highest tertile) (hazard ratio=2.2, 95% confidence interval=1.1-4.7). Low plasma BDNF predicted mortality independently of activities of daily living; education; and a history of central nervous system disease, cerebrovascular accidents, cardiovascular disease, cancer, respiratory disease, and low-grade inflammation. No association was found between plasma BDNF and mortality in men, and serum BDNF did not influence mortality in either sex. CONCLUSION: Low plasma BDNF is a novel, independent, and robust biomarker of mortality risk in old women. BDNF may be a central factor in the network of multimorbidity in old populations.
OBJECTIVES: To test the hypothesis that low circulating brain-derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all-cause mortality in 85-year-old men and women. DESIGN: Longitudinal study with 50- to 58-month follow-up. SETTING: The 1914 cohort, a population-based cohort established in 1964 by the Research Center for Prevention and Health at Glostrup Hospital. PARTICIPANTS: One hundred eighty-eight unselected 85-year-old Danes. MEASUREMENTS: BDNF was measured in plasma and serum. The Danish National Register of Patients was used to collect data on morbidity. The primary outcome in Cox regression analyses was all-cause mortality. RESULTS:Women with low plasma BDNF (lowest tertile) had greater all-cause mortality risk than women with high plasma BDNF (highest tertile) (hazard ratio=2.2, 95% confidence interval=1.1-4.7). Low plasma BDNF predicted mortality independently of activities of daily living; education; and a history of central nervous system disease, cerebrovascular accidents, cardiovascular disease, cancer, respiratory disease, and low-grade inflammation. No association was found between plasma BDNF and mortality in men, and serum BDNF did not influence mortality in either sex. CONCLUSION: Low plasma BDNF is a novel, independent, and robust biomarker of mortality risk in old women. BDNF may be a central factor in the network of multimorbidity in old populations.
Authors: Michelle D Failla; Raj G Kumar; Andrew B Peitzman; Yvette P Conley; Robert E Ferrell; Amy K Wagner Journal: Neurorehabil Neural Repair Date: 2014-07-24 Impact factor: 3.919
Authors: Stefan Spulber; Tomi Rantamäki; Outi Nikkilä; Eero Castrén; Pál Weihe; Philippe Grandjean; Sandra Ceccatelli Journal: Toxicol Sci Date: 2010-07-14 Impact factor: 4.849
Authors: Erin Golden; Ana Emiliano; Stuart Maudsley; B Gwen Windham; Olga D Carlson; Josephine M Egan; Ira Driscoll; Luigi Ferrucci; Bronwen Martin; Mark P Mattson Journal: PLoS One Date: 2010-04-09 Impact factor: 3.240