| Literature DB >> 19514980 |
Azam Bolhassani1, Nahid Ghasemi, Catherine Servis, Mohammad Taghikhani, Sima Rafati.
Abstract
DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat conjugate as a novel gene delivery system on the potency of antigen-specific immunity in mice model. At ratio of 10:50 PEI-Tat/E7DNA (w/w), both humoral and cellular immune responses were significantly enhanced as compared with E7DNA construct and induced Th1 response. Therefore, this new delivery system could have promising applications in gene therapy.Entities:
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Year: 2009 PMID： 19514980 DOI： 10.1080/10717540902757721
Source DB: PubMed Journal: Drug Deliv ISSN： 1071-7544 Impact factor: 6.419