Literature DB >> 19514978

Chitosan glutamate hydrogels with local anesthetic activity for buccal application.

R Pignatello1, L Basile, G Puglisi.   

Abstract

Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were prepared using chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at different weight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of the different formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels was assessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulations containing the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis or other painful mouth diseases.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19514978     DOI： 10.1080/10717540902861267

Source DB:  PubMed          Journal:  Drug Deliv        ISSN： 1071-7544            Impact factor:   6.419


  7 in total

Review 1.  Urban legends: recurrent aphthous stomatitis.

Authors:  L Baccaglini; R V Lalla; A J Bruce; J C Sartori-Valinotti; M C Latortue; M Carrozzo; R S Rogers
Journal:  Oral Dis       Date:  2011-08-04       Impact factor: 3.511

Review 2.  Pain management via local anesthetics and responsive hydrogels.

Authors:  Kyle R Bagshaw; Curt L Hanenbaum; Erica J Carbone; Kevin W H Lo; Cato T Laurencin; Joseph Walker; Lakshmi S Nair
Journal:  Ther Deliv       Date:  2015-02

Review 3.  Emerging Fabrication Strategies of Hydrogels and Its Applications.

Authors:  Fayaz Ali; Imran Khan; Jianmin Chen; Kalsoom Akhtar; Esraa M Bakhsh; Sher Bahadar Khan
Journal:  Gels       Date:  2022-03-24

Review 4.  Current status and future of delivery systems for prevention and treatment of infections in the oral cavity.

Authors:  Sevda Şenel; Ayben Işılay Özdoğan; Gülçin Akca
Journal:  Drug Deliv Transl Res       Date:  2021-03-26       Impact factor: 4.617

5.  Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.

Authors:  Rong-Qin Qi; Wei Liu; Duan-Yu Wang; Fan-Qing Meng; Hong-Ying Wang; Hai-Yan Qi
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.419

6.  Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment.

Authors:  Justyna Chanaj-Kaczmarek; Tomasz Osmałek; Emilia Szymańska; Katarzyna Winnicka; Tomasz M Karpiński; Magdalena Dyba; Marta Bekalarska-Dębek; Judyta Cielecka-Piontek
Journal:  Int J Mol Sci       Date:  2021-10-20       Impact factor: 5.923

7.  Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management.

Authors:  Wentao Deng; Yu Yan; Peipei Zhuang; Xiaoxu Liu; Ke Tian; Wenfang Huang; Cai Li
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.419
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.