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Literature DB >> 1951452

PCR detection of distal Yp sequences in an XX true hermaphrodite.

Y Nakagome¹, S Seki, K Fukutani, S Nagafuchi, Y Nakahori, T Tamura.

Abstract

An XX true hermaphrodite was examined for the presence of Y-specific sequences using Southern-blotting and polymerase chain reaction (PCR) techniques. Of 25 loci examined, only two, the proximal border of the pseudoautosomal region (PABY) and the sex determining region of the Y chromosome (SRY), were detected. A crossing over event in paternal meiosis, proximal to the SRY locus but distal to the zinc finger protein (ZFY) locus, presumably transferred to two loci to the X chromosome.

Entities: Disease Gene

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Year: 1991 PMID： 1951452 DOI： 10.1002/ajmg.1320410127

Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299

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Cited

14 in total

1. Incomplete masculinisation of XX subjects carrying the SRY gene on an inactive X chromosome.

Authors: K Kusz; M Kotecki; A Wojda; M Szarras-Czapnik; A Latos-Bielenska; A Warenik-Szymankiewicz; A Ruszczynska-Wolska; J Jaruzelska
Journal: J Med Genet Date: 1999-06 Impact factor: 6.318

2. Quantitative analysis of microchimerism with Y-chromosome-specific PCR in canine small bowel transplantation.

Authors: T Okuda; N Ichikawa; Y Zhu; H J Chun; A J Demestris; M A Nalesnik; B Rudert; M Trucco; T E Starzl; N Murase
Journal: Transplant Proc Date: 2000-09 Impact factor: 1.066

3. The majority of the marker chromosomes in Japanese patients with stigmata of Turner syndrome are derived from Y chromosomes.

Authors: S Nagafuchi; T Tamura; Y Nakahori; K Takano; Y Nishi; N Iwatani; M Kitao; Y Hori; S Konda; T Hasegawa
Journal: Hum Genet Date: 1992-08 Impact factor: 4.132

4. DNA analyses of XX and XX-hypospadiac males.

Authors: H Numabe; S Nagafuchi; Y Nakahori; T Tamura; H Kiuchi; M Namiki; N Kohda; Y Fukushima; H Fuse; M Kusano
Journal: Hum Genet Date: 1992-11 Impact factor: 4.132

5. Coarctation of the aorta and renal hypoplasia in a boy with Turner/Noonan surface anomalies and a 46,XY karyotype: a clinical model for the possible impairment of a putative lymphogenic gene(s) for Turner somatic stigmata.

Authors: T Hasegawa; T Ogata; Y Hasegawa; M Honda; T Nagai; Y Fukushima; Y Nakahori; N Matsuo
Journal: Hum Genet Date: 1996-05 Impact factor: 4.132

PCR detection of distal Yp sequences in an XX true hermaphrodite.

1. Incomplete masculinisation of XX subjects carrying the SRY gene on an inactive X chromosome.

2. Quantitative analysis of microchimerism with Y-chromosome-specific PCR in canine small bowel transplantation.

3. The majority of the marker chromosomes in Japanese patients with stigmata of Turner syndrome are derived from Y chromosomes.

4. DNA analyses of XX and XX-hypospadiac males.

5. Coarctation of the aorta and renal hypoplasia in a boy with Turner/Noonan surface anomalies and a 46,XY karyotype: a clinical model for the possible impairment of a putative lymphogenic gene(s) for Turner somatic stigmata.

Review 6. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.

Review 7. [Genetics of human sex determination and its disturbances].

8. Infusion of donor leukocytes to induce tolerance in organ allograft recipients.

9. Systemic chimerism in human female recipients of male livers.

Review 10. True hermaphroditism: geographical distribution, clinical findings, chromosomes and gonadal histology.