Moderate hypobaric hypoxia modifies Ca2+-mediated glutamatergic signal transduction in rat cerebral cortex.

Examination of fluorescent Ca(2+)-responses to stimulation by ionotropic glutamate receptor agonists in rat cerebral cortex slices, preconditioned with hypobaric hypoxia, has demonstrated different time course for up-regulation of their Ca(2+)-conductivity and for stimulation of the consequent binding of the Ca(2+) which entered the cell. The evident result is the development of AMPA-mediated moderate increase of intracellular Ca(2+).