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Literature DB >> 19513348

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.

Abstract

The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small GTPases - Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily conserved role in many cellular processes. Six human PAKs have been identified, and based on homology, they can be classified into two groups. This review focuses specifically on the role of Rac/Cdc42 regulated PAKs in maintaining and remodeling cytoskeletal structure in various organisms. A list of PAKs substrates and binding partners implicated directly and indirectly in cytoskeletal reorganization is presented. Also perturbations of the Rac/Cdc42/PAK pathway leading to tumorigenesis and neurodegenerative diseases are reviewed.

Entities: Disease Gene Species

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Year: 2009 PMID： 19513348

Source DB: PubMed Journal: Acta Biochim Pol ISSN： 0001-527X Impact factor: 2.149

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Cited

36 in total

1. Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds.

Authors: Norman F Truong; Sasha Cai Lesher-Pérez; Evan Kurt; Tatiana Segura
Journal: Bioconjug Chem Date: 2018-12-18 Impact factor: 4.774

2. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

Authors: Lulu Y Chen; Christopher S Rex; Alex H Babayan; Eniko A Kramár; Gary Lynch; Christine M Gall; Julie C Lauterborn
Journal: J Neurosci Date: 2010-08-18 Impact factor: 6.167

3. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

Authors: Dany Arsenault; Alexandre Dal-Pan; Cyntia Tremblay; David A Bennett; Matthieu J Guitton; Yves De Koninck; Susumu Tonegawa; Frédéric Calon
Journal: J Neurosci Date: 2013-06-26 Impact factor: 6.167

4. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

Authors: Maria Radu; Sonali J Rawat; Alexander Beeser; Anton Iliuk; Weiguo Andy Tao; Jonathan Chernoff
Journal: J Biol Chem Date: 2013-06-11 Impact factor: 5.157

Review 5. P21 activated kinases: structure, regulation, and functions.

Authors: Chetan K Rane; Audrey Minden
Journal: Small GTPases Date: 2014-03-21

Review 6. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation.

Authors: Gary Lynch; Enikö A Kramár; Alex H Babayan; Gavin Rumbaugh; Christine M Gall
Journal: Neuropharmacology Date: 2012-07-20 Impact factor: 5.250

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.

1. Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds.

2. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

3. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

4. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.

Review 5. P21 activated kinases: structure, regulation, and functions.

Review 6. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation.

7. Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1.

8. Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses.

9. Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.

Review 10. Targeting calpain in synaptic plasticity.