OBJECTIVE: To compare the analgesic and motor-blocking effects of epidurally administered levobupivacaine and bupivacaine in the conscious dog. STUDY DESIGN: Prospective, randomized, cross-over study. ANIMALS: Six adult female Beagle dogs. METHODS: Each animal received three doses of levobupivacaine or bupivacaine (0.5, 1.0 and 1.5 mg kg(-1); concentrations 0.25%, 0.50%, and 0.75%, respectively) in a total volume of 0.2 mL kg(-1) by means of a chronically implanted epidural catheter. Onset, duration (through pinch response in the sacral, lumbar and toe areas) and degree of analgesia and motor-blocking status was determined with a scoring system and at regular intervals over 8.5 hours before (baseline) and after drug administration. RESULTS: Epidurally administered levobupivacaine and bupivacaine had a similar dose-dependent analgesic action with no significant differences in onset (range: 5-8 minutes), duration (bupivacaine: 42 +/- 28, 135 +/- 68 and 265 +/- 68 minutes, and levobupivacaine: 28 +/- 33, 79 +/- 55 and 292 +/- 133 minutes; 0.25%, 0.50%, and 0.75%, respectively) or maximum degree of analgesia. However, levobupivacaine tended to produce a shorter duration of motor block than bupivacaine and the difference in the motor to nociceptive blockade times was significant at the highest dose. CONCLUSION: Epidural levobupivacaine produced an analgesic action similar to that of bupivacaine. CLINICAL RELEVANCE: Epidural levobupivacaine is suitable for clinical use in dogs, mostly at the highest dose if a high degree of analgesia is required.
OBJECTIVE: To compare the analgesic and motor-blocking effects of epidurally administered levobupivacaine and bupivacaine in the conscious dog. STUDY DESIGN: Prospective, randomized, cross-over study. ANIMALS: Six adult female Beagle dogs. METHODS: Each animal received three doses of levobupivacaine or bupivacaine (0.5, 1.0 and 1.5 mg kg(-1); concentrations 0.25%, 0.50%, and 0.75%, respectively) in a total volume of 0.2 mL kg(-1) by means of a chronically implanted epidural catheter. Onset, duration (through pinch response in the sacral, lumbar and toe areas) and degree of analgesia and motor-blocking status was determined with a scoring system and at regular intervals over 8.5 hours before (baseline) and after drug administration. RESULTS: Epidurally administered levobupivacaine and bupivacaine had a similar dose-dependent analgesic action with no significant differences in onset (range: 5-8 minutes), duration (bupivacaine: 42 +/- 28, 135 +/- 68 and 265 +/- 68 minutes, and levobupivacaine: 28 +/- 33, 79 +/- 55 and 292 +/- 133 minutes; 0.25%, 0.50%, and 0.75%, respectively) or maximum degree of analgesia. However, levobupivacaine tended to produce a shorter duration of motor block than bupivacaine and the difference in the motor to nociceptive blockade times was significant at the highest dose. CONCLUSION: Epidural levobupivacaine produced an analgesic action similar to that of bupivacaine. CLINICAL RELEVANCE: Epidural levobupivacaine is suitable for clinical use in dogs, mostly at the highest dose if a high degree of analgesia is required.
Authors: Manuel Martin-Flores; Justine C Anderson; Daniel M Sakai; Luis Campoy; Soon Hon Cheong; Marta Romano; Robin D Gleed Journal: Can Vet J Date: 2019-12 Impact factor: 1.008
Authors: Raquel Sartori Gonçalves Dias; João Henrique Neves Soares; Douglas Dos Santos E Castro; Maria Alice Kuster de Albuquerque Gress; Marcela Lemos Machado; Pablo E Otero; Fabio Otero Ascoli Journal: PLoS One Date: 2018-04-18 Impact factor: 3.240