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Literature DB >> 19508210

Molecular modeling of human BAD, a pro-apoptotic Bcl-2 family member, integrating glycolysis and apoptosis.

Abstract

Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of BAD.

Entities: Chemical Gene Species

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Year: 2010 PMID： 19508210 DOI： 10.2174/092986610790226003

Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890

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Authors: Zhihong Chen; Yaqiang He; Chengjun Song; Zhijun Dong; Zhejun Su; Jingfeng Xue
Journal: Neural Regen Res Date: 2012-01-25 Impact factor: 5.135

1 in total