| Literature DB >> 195081 |
S V Kashmiri, A Rein, R H Bassin, B I Gerwin, S Gisselbrecht.
Abstract
The IC isolate of Moloney murine leukemia virus (MuLV), which is NB-tropic, was grown in cells producing conditionally defective or defective virus particles derived from N- or B-tropic MuLV. The infectious MuLV that was then released was found to be sensitive to Fv-1 restriction but produced NB-tropic progeny upon passage. These results indicate that this NB-tropic MuLV can acquire sensitivity to Fv-1 restriction by phenotypic mixing with N- or B-tropic MuLV. It is thus suggested that NB-tropic MuLV is insensitive to Fv-1 restriction simply because it lacks the determinants of tropism.Entities:
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Year: 1977 PMID: 195081 PMCID: PMC515761
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103