| Literature DB >> 19507847 |
Hwan Jung Lim1, T V RajanBabu.
Abstract
Seleniranium ions at low temperatures (-90 to -78 degrees C) will initiate effective Friedel-Crafts cyclization if a suitably placed arene is allowed to react even when the arene is unactivated. These intermediates generated from N-aryl-N-tosylamides undergo a novel, surprisingly efficient, detosylative cyclization to form 5- or 6-membered nitrogen heterocycles. A debenzylation route is preferred if both benzyl and tosyl groups are present in the substrate.Entities:
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Year: 2009 PMID： 19507847 PMCID： PMC2742950 DOI： 10.1021/ol900961m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005