Celiac plexus neurolysis for pain relief in pancreatic cancer.

Palliation of pain in pancreatic cancer often requires a multidisciplinary approach, with options including oral analgesics, chemoradiotherapy, and celiac plexus neurolysis (CPN). Although CPN may be performed endoscopically, percutaneously, or surgically, endoscopic ultrasonography (EUS)-guided CPN is becoming more commonplace, given the overall improved real-time visualization and reduced risk of major (neurologic) complications. Regardless of the technique used, CPN may have a long-lasting benefit in between 70% and 90% of patients with pancreatic cancer.