BACKGROUND/ OBJECTIVES: Subjects affected by mild cognitive impairment (MCI) may improve during the observation period. This is the first study investigating qualitative features of memory deficits in subjects affected by reversible MCI [reversible cognitive impairment (RCI)]. METHODS: Baseline cognitive and memory performances of 18 subjects affected by amnestic MCI who had normalized cognitive performances at follow-ups were compared with those of 76 amnestic MCI subjects who still showed impaired cognitive performances at the 24-month follow-up (MCI) and with those of a group of 87 matched control subjects (normal controls). RESULTS: Compared with normal controls the memory deficit in the MCI group affected all aspects of explicit long-term memory functioning; in the RCI group, instead, the memory deficit only affected the free recall of verbal material, particularly when the encoding could be improved by the use of semantic strategies. CONCLUSIONS: These results are consistent with the view that the memory deficit in the MCI group is due to a very early degenerative pathology; in the RCI group, instead, a transitory reduction of processing resources, resulting a poor encoding of incoming material, is likely at the origin of the reversible memory disorder.
BACKGROUND/ OBJECTIVES: Subjects affected by mild cognitive impairment (MCI) may improve during the observation period. This is the first study investigating qualitative features of memory deficits in subjects affected by reversible MCI [reversible cognitive impairment (RCI)]. METHODS: Baseline cognitive and memory performances of 18 subjects affected by amnestic MCI who had normalized cognitive performances at follow-ups were compared with those of 76 amnestic MCI subjects who still showed impaired cognitive performances at the 24-month follow-up (MCI) and with those of a group of 87 matched control subjects (normal controls). RESULTS: Compared with normal controls the memory deficit in the MCI group affected all aspects of explicit long-term memory functioning; in the RCI group, instead, the memory deficit only affected the free recall of verbal material, particularly when the encoding could be improved by the use of semantic strategies. CONCLUSIONS: These results are consistent with the view that the memory deficit in the MCI group is due to a very early degenerative pathology; in the RCI group, instead, a transitory reduction of processing resources, resulting a poor encoding of incoming material, is likely at the origin of the reversible memory disorder.
Authors: Maria Stefania De Simone; Roberta Perri; Lucia Fadda; Massimo De Tollis; Chiara Stella Turchetta; Carlo Caltagirone; Giovanni Augusto Carlesimo Journal: J Neurol Date: 2017-09-25 Impact factor: 4.849
Authors: Maria Stefania De Simone; Massimo De Tollis; Lucia Fadda; Roberta Perri; Carlo Caltagirone; Giovanni Augusto Carlesimo Journal: J Neurol Date: 2019-09-30 Impact factor: 4.849
Authors: Marco Bozzali; Geoff J M Parker; Barbara Spanò; Laura Serra; Giovanni Giulietti; Roberta Perri; Giuseppe Magnani; Camillo Marra; Maria G Vita; Carlo Caltagirone; Mara Cercignani Journal: Hum Brain Mapp Date: 2012-06-19 Impact factor: 5.038
Authors: Ciaran M Considine; Sara L Weisenbach; Sara J Walker; E Michelle McFadden; Lindsay M Franti; Linas A Bieliauskas; Daniel F Maixner; Bruno Giordani; Stanley Berent; Scott A Langenecker Journal: Arch Clin Neuropsychol Date: 2011-05-18 Impact factor: 2.813
Authors: Maria Stefania De Simone; Roberta Perri; Lucia Fadda; Carlo Caltagirone; Giovanni Augusto Carlesimo Journal: J Neurol Date: 2018-11-01 Impact factor: 4.849