Literature DB >> 19502905

Fatal pancytopenia in a hemodialysis patient after treatment with low-dose methotrexate.

Kitty Kit Ting Cheung1, Kai Ming Chow, Cheuk Chun Szeto, Morris Hok Leung Tai, Bonnie Ching Ha Kwan, Philip Kam Tao Li.   

Abstract

We report a 56-year-old male hemodialysis patient who developed fatal pancytopenia after treatment with low-dose methotrexate for psoriasis and psoriatic arthropathy. Risk factors identified included impaired renal function, concurrent use of nonsteroidal anti-inflammatory drugs, low serum albumin, and relatively low serum folate level. Literature review found similar risk factors in 12 other cases. Therefore, methotrexate, even as a single dose, should not be used to treat rheumatic conditions in dialysis patients.

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Year:  2009        PMID： 19502905     DOI： 10.1097/RHU.0b013e3181a61f2d

Source DB:  PubMed          Journal:  J Clin Rheumatol        ISSN： 1076-1608            Impact factor:   3.517


  8 in total

1.  High dose methotrexate and extended hours high-flux hemodialysis for the treatment of primary central nervous system lymphoma in a patient with end stage renal disease.

Authors:  Howard Mutsando; Magid Fahim; Devinder S Gill; Carmel M Hawley; David W Johnson; Maher K Gandhi; Paula V Marlton; Helen G Mar Fan; Peter N Mollee
Journal:  Am J Blood Res       Date:  2012-01-01

Review 2.  Methotrexate for rheumatoid arthritis patients who are on hemodialysis.

Authors:  Hasanein Al-Hasani; Euthalia Roussou
Journal:  Rheumatol Int       Date:  2011-07-22       Impact factor: 2.631

3.  Almost a tragedy: severe methotrexate toxicity in a hemodialysis patient treated for ectopic pregnancy.

Authors:  Nadav Willner; Shimon Storch; Tamar Tadmor; Elad Schiff
Journal:  Eur J Clin Pharmacol       Date:  2013-11-26       Impact factor: 2.953

Review 4.  Renal co-morbidity in patients with rheumatic diseases.

Authors:  Hans-Joachim Anders; Volker Vielhauer
Journal:  Arthritis Res Ther       Date:  2011-06-29       Impact factor: 5.156

5.  Bilateral septic knee arthritis after treatment of an ectopic pregnancy with methotrexate.

Authors:  Fatih Karaaslan; Musa Uğur Mermerkaya; Emre Yurdakul; Özlem Tanın
Journal:  Int Med Case Rep J       Date:  2015-01-13

6.  Chemotherapy for non-Hodgkin lymphoma in the hemodialysis patient: A comprehensive review.

Authors:  Hajime Yasuda; Mutsuko Yasuda; Norio Komatsu
Journal:  Cancer Sci       Date:  2021-06-11       Impact factor: 6.716

Review 7.  Successful multiple-exchange peritoneal dialysis in a patient with severe hematological toxicity by methotrexate: case report and literature review.

Authors:  Arbey Aristizabal-Alzate; John Fredy Nieto-Rios; Catalina Ocampo-Kohn; Lina Maria Serna-Higuita; Diana Carolina Bello-Marquez; Gustavo Adolfo Zuluaga-Valencia
Journal:  J Bras Nefrol       Date:  2018-09-21

8.  Medication Error- A Case Report of Misadventure with Methotrexate.

Authors:  Anup Singh; Aru Chhabra Handa
Journal:  JNMA J Nepal Med Assoc       Date:  2018 Mar-Apr       Impact factor: 0.406
  8 in total

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