Literature DB >> 19501957

Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells.

Mengsen Li1, Hui Li, Chaoying Li, Liyuan Guo, Han Liu, Sheng Zhou, Xinhua Liu, Zhuo Chen, Shuanglin Shi, Jiang Wei, Michael A McNutt, Gang Li.   

Abstract

The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-beta were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-beta into the nucleus via competitive binding to RAR-beta with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA.

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Year:  2009        PMID： 19501957     DOI： 10.1016/j.canlet.2009.05.014

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  29 in total

1.  Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma.

Authors:  Peng Li; Shan-Shan Wang; Hui Liu; Ning Li; Michael A McNutt; Gang Li; Hui-Guo Ding
Journal:  World J Gastroenterol       Date:  2011-11-07       Impact factor: 5.742

2.  GATA5 inhibits hepatocellular carcinoma cells malignant behaviours by blocking expression of reprogramming genes.

Authors:  Haipeng Feng; Mingyue Zhu; Ruizhu Zhang; Qiaoyun Wang; Wei Li; Xu Dong; Yi Chen; Yan Lu; Kun Liu; Bo Lin; Junli Guo; Mengsen Li
Journal:  J Cell Mol Med       Date:  2019-01-22       Impact factor: 5.310

3.  Nonsecreted cytoplasmic alpha-fetoprotein: a newly discovered role in intracellular signaling and regulation. An update and commentary.

Authors:  G J Mizejewski
Journal:  Tumour Biol       Date:  2015-07-12

Review 4.  Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.

Authors:  G J Mizejewski
Journal:  Tumour Biol       Date:  2013-02-28

5.  Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma.

Authors:  Yongping Yang; Yinying Lu; Chunping Wang; Wenlin Bai; Jianhui Qu; Yan Chen; Xiujuan Chang; Linjing An; Lin Zhou; Zhen Zeng; Min Lou; Jiyun Lv
Journal:  Exp Ther Med       Date:  2011-12-01       Impact factor: 2.447

Review 6.  Alpha-fetoprotein: a renaissance.

Authors:  A A Terentiev; N T Moldogazieva
Journal:  Tumour Biol       Date:  2013-06-14

7.  Translocatome: a novel resource for the analysis of protein translocation between cellular organelles.

Authors:  Péter Mendik; Levente Dobronyi; Ferenc Hári; Csaba Kerepesi; Leonardo Maia-Moço; Donát Buszlai; Peter Csermely; Daniel V Veres
Journal:  Nucleic Acids Res       Date:  2019-01-08       Impact factor: 16.971

8.  Transarterial chemoembolization with/without cryotherapy is associated with improved clinical outcomes of sorafenib for the treatment of advanced hepatocellular carcinoma.

Authors:  Chunping Wang; Yinying Lu; Hong Wang; Xudong Gao; Wenlin Bai; Jianhui Qu; Guilin Xu; Zhenzhen Zhang; Zhen Zeng; Lin Zhou; Linjing An; Jiyun Lv; Yongping Yang
Journal:  Exp Ther Med       Date:  2012-05-10       Impact factor: 2.447

9.  Relationship of α-fetoprotein levels and development of hepatocellular carcinoma in hepatitis C patients with liver cirrhosis.

Authors:  Naota Taura; Sachiko Fukuda; Tatsuki Ichikawa; Hisamitsu Miyaaki; Hidetaka Shibata; Takuya Honda; Tohei Yamaguchi; Yoko Kubota; Shinjiro Uchida; Yasuhiro Kamo; Emi Yoshimura; Hajime Isomoto; Takehiro Matsumoto; Fuminao Takeshima; Takuya Tsutsumi; Shotaro Tsuruta; Kazuhiko Nakao
Journal:  Exp Ther Med       Date:  2012-09-17       Impact factor: 2.447

10.  Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells.

Authors:  Yanfei Jia; Dezhi Liu; Dongjie Xiao; Xiaoli Ma; Shuyi Han; Yan Zheng; Shanhui Sun; Maoxiu Zhang; Hongmei Gao; Xia Cui; Yunshan Wang
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240
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