Obesity and metabolic disease.

Obesity independently increases the risk of developing diabetes 10-fold compared with that for patients who are normal weight. Overweight patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) should be given counseling on weight loss of 5% to 10% of body weight as well as on increasing physical activity to at least 150 min/wk to prevent progression to diabetes. American Diabetes Association (ADA) recommends screening patients older than 45 years with a body mass index (BMI) greater than or equal to 25 for diabetes with fasting glucose every 3 years. Testing should be considered at a younger age or performed more frequently for those who are overweight and have 1 or more risk factors for diabetes.