| Literature DB >> 19501147 |
Maria Elenir N P Ribeiro1, Icaro G P Vieira, Igor Marques Cavalcante, Nágila M P S Ricardo, David Attwood, Stephen G Yeates, Colin Booth.
Abstract
The solubilisation of two poorly soluble flavonoids, quercetin and rutin, in micellar solutions of mixtures of a block copolymer of ethylene oxide and styrene oxide (E(137)S(18)E(137)) with one of ethylene oxide and propylene oxide (E(62)P(39)E(62)) has been studied at 25 and 37 degrees C. Solubilisation capacities were higher than those for the model poorly water-soluble drug griseofulvin and comparable with published values for the solubilisation of rutin by beta-cyclodextrin.Entities:
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Year: 2009 PMID： 19501147 DOI： 10.1016/j.ijpharm.2009.05.047
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875