Literature DB >> 19500655

Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain.

James P Kesby1, Xiaoying Cui, Pauline Ko, John J McGrath, Thomas H J Burne, Darryl W Eyles.   

Abstract

There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development.

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Year:  2009        PMID： 19500655     DOI： 10.1016/j.neulet.2009.05.070

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  44 in total

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5.  MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex.

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7.  HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function.

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9.  Developmental vitamin D deficiency alters MK-801-induced behaviours in adult offspring.

Authors:  James P Kesby; Jonathan C O'Loan; Suzanne Alexander; Chao Deng; Xu-Feng Huang; John J McGrath; Darryl W Eyles; Thomas H J Burne
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10.  Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats.

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Journal:  Psychopharmacology (Berl)       Date:  2009-11-18       Impact factor: 4.530
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