T Ritzenthaler1, J-M Verret, J Honnorat. 1. Service de neurologie B, hôpital neurologique Pierre-Wertheimer, 59, boulevard Pinel, 69677 Bron, France.
Abstract
INTRODUCTION: Paraneoplastic movement disorders are rare. Reported cases frequently describe association with anti-CV2/CRMP5 antibodies. CASE REPORT: We report a case of an 80-year-old man who developed sensorial neuronopathy, following by movement disorders mimicking chorea and obsessive-compulsive and behavioral disorders. These manifestations were first considered to be associated with a prostatic adenocarcinoma but PET and surgical biopsy revealed a mediastinal small cell lung carcinoma classically associated with anti-CV2/CRMP5 antibodies. CONCLUSION: This case demonstrates that in a context of paraneoplastic neurological syndrome, search for a classically associated cancer is necessary in order to institute adapted treatment early, even if another tumor is obvious. Copyright 2009 Elsevier Masson SAS. All rights reserved.
INTRODUCTION:Paraneoplastic movement disorders are rare. Reported cases frequently describe association with anti-CV2/CRMP5 antibodies. CASE REPORT: We report a case of an 80-year-old man who developed sensorial neuronopathy, following by movement disorders mimicking chorea and obsessive-compulsive and behavioral disorders. These manifestations were first considered to be associated with a prostatic adenocarcinoma but PET and surgical biopsy revealed a mediastinal small cell lung carcinoma classically associated with anti-CV2/CRMP5 antibodies. CONCLUSION: This case demonstrates that in a context of paraneoplastic neurological syndrome, search for a classically associated cancer is necessary in order to institute adapted treatment early, even if another tumor is obvious. Copyright 2009 Elsevier Masson SAS. All rights reserved.
Authors: A Aliprandi; A Terruzzi; A Rigamonti; E Bazzigaluppi; L Tremolizzo; C Ferrarese; A Salmaggi Journal: Neurol Sci Date: 2015-02-17 Impact factor: 3.307