Literature DB >> 19496332

Light-induced release of A2E photooxidation toxic products from lipofuscin granules of human retinal pigment epithelium.

A E Dontsov1, N L Sakina, A M Golubkov, M A Ostrovsky.   

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Year:  2009        PMID： 19496332     DOI： 10.1134/s1607672909020112

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


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  15 in total

Review 1.  Pathogenesis of lesions in late age-related macular disease.

Authors:  Frank G Holz; Daniel Pauleikhoff; Ronald Klein; Alan C Bird
Journal:  Am J Ophthalmol       Date:  2004-03       Impact factor: 5.258

2.  Retinal pigment epithelium cell damage by A2-E and its photo-derivatives.

Authors:  Martin Hammer; Sandra Richter; Karl-Heinz Guehrs; Dietrich Schweitzer
Journal:  Mol Vis       Date:  2006-11-01       Impact factor: 2.367

3.  The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells.

Authors:  Xinyu Zhang; Jilin Zhou; Alexandre F Fernandes; Janet R Sparrow; Paulo Pereira; Allen Taylor; Fu Shang
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-04-11       Impact factor: 4.799

4.  Oxidation of A2E results in the formation of highly reactive aldehydes and ketones.

Authors:  Zhen Wang; Lanea M M Keller; James Dillon; Elizabeth R Gaillard
Journal:  Photochem Photobiol       Date:  2006 Sep-Oct       Impact factor: 3.421

5.  Detection and study of the products of photooxidation of N-retinylidene-N-retinylethanolamine (A2E), the fluorophore of lipofuscin granules from retinal pigment epithelium of human donor eyes.

Authors:  M A Yakovleva; N L Sakina; A S Kononikhin; T B Feldman; E N Nikolaev; A E Dontsov; M A Ostrovsky
Journal:  Dokl Biochem Biophys       Date:  2006 Jul-Aug       Impact factor: 0.788

6.  Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Authors:  Janet R Sparrow; Jilin Zhou; Shimon Ben-Shabat; Heidi Vollmer; Yasuhiro Itagaki; Koji Nakanishi
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-04       Impact factor: 4.799

7.  Interaction of pyridinium bis-retinoid (A2E) with bilayer lipid membranes.

Authors:  V S Sokolov; E A Sokolenko; A V Sokolov; A E Dontsov; Y A Chizmadzhev; M A Ostrovsky
Journal:  J Photochem Photobiol B       Date:  2006-10-27       Impact factor: 6.252

8.  The photochemical oxidation of A2E results in the formation of a 5,8,5',8'-bis-furanoid oxide.

Authors:  J Dillon; Z Wang; L B Avalle; E R Gaillard
Journal:  Exp Eye Res       Date:  2004-10       Impact factor: 3.467

9.  Lipofuscin is a photoinducible free radical generator.

Authors:  M Boulton; A Dontsov; J Jarvis-Evans; M Ostrovsky; D Svistunenko
Journal:  J Photochem Photobiol B       Date:  1993-08       Impact factor: 6.252

10.  Comparison of photosensitizing effect of lipofuscin granules from retinal pigment epithelium of human donor eyes and their fluorophore A2E.

Authors:  A E Dontsov; N L Sakina; B Bilinska; L Krzyzanowski; T B Feldman; M A Ostrovsky
Journal:  Dokl Biochem Biophys       Date:  2005 Nov-Dec       Impact factor: 0.788
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  11 in total

1.  Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.

Authors:  Konstantin Petrukhin
Journal:  Drug Discov Today Ther Strateg       Date:  2013

2.  Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.

Authors:  Christopher L Cioffi; Boglarka Racz; Emily E Freeman; Michael P Conlon; Ping Chen; Douglas G Stafford; Daniel M C Schwarz; Lei Zhu; Douglas B Kitchen; Keith D Barnes; Nicoleta Dobri; Enrique Michelotti; Charles L Cywin; William H Martin; Paul G Pearson; Graham Johnson; Konstantin Petrukhin
Journal:  J Med Chem       Date:  2015-08-04       Impact factor: 7.446

Review 3.  Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age.

Authors:  T B Feldman; A E Dontsov; M A Yakovleva; M A Ostrovsky
Journal:  Biophys Rev       Date:  2022-08-08

4.  Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.

Authors:  Christopher L Cioffi; Nicoleta Dobri; Emily E Freeman; Michael P Conlon; Ping Chen; Douglas G Stafford; Daniel M C Schwarz; Kathy C Golden; Lei Zhu; Douglas B Kitchen; Keith D Barnes; Boglarka Racz; Qiong Qin; Enrique Michelotti; Charles L Cywin; William H Martin; Paul G Pearson; Graham Johnson; Konstantin Petrukhin
Journal:  J Med Chem       Date:  2014-09-11       Impact factor: 7.446

5.  Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits.

Authors:  Jackie Penn; Doina M Mihai; Ilyas Washington
Journal:  Dis Model Mech       Date:  2014-12-12       Impact factor: 5.758

6.  Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls.

Authors:  Marina Yakovleva; Alexander Dontsov; Natalia Trofimova; Natalia Sakina; Alexey Kononikhin; Arseny Aybush; Alexander Gulin; Tatiana Feldman; Mikhail Ostrovsky
Journal:  Int J Mol Sci       Date:  2021-12-25       Impact factor: 5.923

7.  Vitamin A cycle byproducts explain retinal damage and molecular changes thought to initiate retinal degeneration.

Authors:  Dan Zhang; Doina M Mihai; Ilyas Washington
Journal:  Biol Open       Date:  2021-11-29       Impact factor: 2.422

8.  Water-Soluble Products of Photooxidative Destruction of the Bisretinoid A2E Cause Proteins Modification in the Dark.

Authors:  Alexander Dontsov; Marina Yakovleva; Natalia Trofimova; Natalia Sakina; Alexander Gulin; Arseny Aybush; Fedor Gostev; Alexander Vasin; Tatiana Feldman; Mikhail Ostrovsky
Journal:  Int J Mol Sci       Date:  2022-01-28       Impact factor: 5.923

9.  Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.

Authors:  Christopher L Cioffi; Parthasarathy Muthuraman; Arun Raja; Andras Varadi; Boglarka Racz; Konstantin Petrukhin
Journal:  J Med Chem       Date:  2020-09-17       Impact factor: 8.039

10.  Variability of the transferrin receptor 2 gene in AMD.

Authors:  Daniel Wysokinski; Janusz Blasiak; Mariola Dorecka; Marta Kowalska; Jacek Robaszkiewicz; Elzbieta Pawlowska; Jerzy Szaflik; Jacek Pawel Szaflik
Journal:  Dis Markers       Date:  2014-02-06       Impact factor: 3.434
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