Literature DB >> 19496082

Single-molecule mechanical unfolding of amyloidogenic beta2-microglobulin: the force-spectroscopy approach.

B Sorce1, S Sabella, M Sandal, B Samorì, A Santino, R Cingolani, R Rinaldi, P P Pompa.   

Abstract

The recombinant production of a novel chimeric polyprotein is described. The new protein contains either wild-type beta(2)-microglobulin (beta(2)m) or its truncated variant (DeltaN6 beta(2)m) (see picture). Structural characterization is achieved by means of single-molecule force spectroscopy studies of specific beta(2)m regions which could be involved in amyloidogenesis.

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Year:  2009        PMID: 19496082     DOI: 10.1002/cphc.200900220

Source DB:  PubMed          Journal:  Chemphyschem        ISSN: 1439-4235            Impact factor:   3.102


  2 in total

1.  Nonkinetic modeling of the mechanical unfolding of multimodular proteins: theory and experiments.

Authors:  F Benedetti; C Micheletti; G Bussi; S K Sekatskii; G Dietler
Journal:  Biophys J       Date:  2011-09-20       Impact factor: 4.033

Review 2.  Nanoimaging for prion related diseases.

Authors:  Alexey V Krasnoslobodtsev; Alexander M Portillo; Tanja Deckert-Gaudig; Volker Deckert; Yuri L Lyubchenko
Journal:  Prion       Date:  2010-10-23       Impact factor: 3.931

  2 in total

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