Literature DB >> 19493602

Fanconi syndrome due to deferasirox.

Cédric Rafat1, Fadi Fakhouri, Jean-Antoine Ribeil, Richard Delarue, Moglie Le Quintrec.   

Abstract

Deferasirox is an innovative iron-chelating treatment. However, preliminary data have suggested that kidney toxicity may be a major issue in the management of patients receiving this drug. We report a case of Fanconi syndrome associated with acute renal insufficiency in a patient receiving deferasirox. The latter has to be added to the expanding list of drugs that may induce Fanconi syndrome. Careful monitoring of kidney function and markers of proximal tubular injury are mandatory in patients undergoing treatment with deferasirox.

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Year:  2009        PMID: 19493602     DOI: 10.1053/j.ajkd.2009.03.013

Source DB:  PubMed          Journal:  Am J Kidney Dis        ISSN: 0272-6386            Impact factor:   8.860


  13 in total

Review 1.  Deferasirox for managing iron overload in people with thalassaemia.

Authors:  Claudia Bollig; Lisa K Schell; Gerta Rücker; Roman Allert; Edith Motschall; Charlotte M Niemeyer; Dirk Bassler; Joerg J Meerpohl
Journal:  Cochrane Database Syst Rev       Date:  2017-08-15

2.  Renal Fanconi syndrome secondary to deferasirox: where there is smoke there is fire.

Authors:  Michel Baum
Journal:  J Pediatr Hematol Oncol       Date:  2010-10       Impact factor: 1.289

Review 3.  Deferasirox nephrotoxicity-the knowns and unknowns.

Authors:  Juan Daniel Díaz-García; Angel Gallegos-Villalobos; Liliana Gonzalez-Espinoza; Maria D Sanchez-Niño; Jesus Villarrubia; Alberto Ortiz
Journal:  Nat Rev Nephrol       Date:  2014-07-22       Impact factor: 28.314

4.  Deferasirox-induced renal impairment in children: an increasing concern for pediatricians.

Authors:  Laurence Dubourg; Céline Laurain; Bruno Ranchin; Corinne Pondarré; Aoumeur Hadj-Aïssa; Dominique Sigaudo-Roussel; Pierre Cochat
Journal:  Pediatr Nephrol       Date:  2012-04-24       Impact factor: 3.714

Review 5.  Drug-Induced Metabolic Acidosis.

Authors:  Amy Quynh Trang Pham; Li Hao Richie Xu; Orson W Moe
Journal:  F1000Res       Date:  2015-12-16

6.  Acute kidney injury due to thin basement membrane disease mimicking Deferasirox nephrotoxicity: a case report.

Authors:  Keiko Oda; Kan Katayama; Akiko Tanoue; Tomohiro Murata; Yumi Hirota; Shoko Mizoguchi; Yosuke Hirabayashi; Takayasu Ito; Eiji Ishikawa; Kaoru Dohi; Masaaki Ito
Journal:  BMC Nephrol       Date:  2018-12-17       Impact factor: 2.388

Review 7.  Deferasirox: Over a Decade of Experience in Thalassemia.

Authors:  Nour M Moukalled; Rayan Bou-Fakhredin; Ali T Taher
Journal:  Mediterr J Hematol Infect Dis       Date:  2018-11-01       Impact factor: 2.576

8.  The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability.

Authors:  Esther M Gottwald; Claus D Schuh; Patrick Drücker; Dominik Haenni; Adam Pearson; Susan Ghazi; Milica Bugarski; Marcello Polesel; Michael Duss; Ehud M Landau; Andres Kaech; Urs Ziegler; Anne K M Lundby; Carsten Lundby; Petra S Dittrich; Andrew M Hall
Journal:  Sci Rep       Date:  2020-01-31       Impact factor: 4.379

Review 9.  Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series.

Authors:  Valeria Maria Pinto; Gian Luca Forni
Journal:  Int J Mol Sci       Date:  2020-11-20       Impact factor: 5.923

10.  Cost-utility analysis of deferiprone for the treatment of β-thalassaemia patients with chronic iron overload: a UK perspective.

Authors:  Anthony Bentley; Samantha Gillard; Michael Spino; John Connelly; Fernando Tricta
Journal:  Pharmacoeconomics       Date:  2013-09       Impact factor: 4.981

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