| Literature DB >> 19493058 |
Abstract
Recent work has implicated a novel Th effector cell subset, the Th17 cell subset, in the development of both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) because of the ability of Th17 cells to produce cytokines like IL-17 and IL-21 that can drive both inflammatory and humoral responses. In this review, we will discuss recent studies that have begun elucidating the factors that regulate the development of Th17 cells and provide a brief overview of the role of Th17 cells in RA and SLE.Entities:
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Year: 2009 PMID: 19493058 DOI: 10.1111/j.1365-2796.2009.02099.x
Source DB: PubMed Journal: J Intern Med ISSN: 0954-6820 Impact factor: 8.989